Table of Contents
ISRN Rheumatology
Volume 2011, Article ID 654027, 4 pages
Clinical Study

Osteoporosis and Bisphosphonate-Related Osteonecrosis of the Jaw Bone

Dental Clinic, Department of Medicine, Surgery and Dentistry, University of Milano, 20142 Milano, Italy

Received 1 April 2011; Accepted 3 May 2011

Academic Editor: A. Sudo

Copyright © 2011 Alessandro Villa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this longitudinal study is to present data from 76 female patients treated with bisphosphonates (BPs) for postmenopausal osteoporosis and referred to the Unit of Oral Diagnosis and Day Surgery of the University of Milano for diagnosis and treatment. All patients received a thorough oral examination. The diagnosis of osteonecrosis of the jaw bone (ONJ) was made from radiographic and clinical findings. 9% of individuals had BRONJ at first visit. Patients with dental or periodontal abscess were significantly more likely to develop BRONJ (OR: 2.9, 95% CI 0.5–15.9). Patients with osteoporosis receiving BPs may develop BRONJ, especially in the presence of an active infectious process in the mouth. Clinicians should carefully follow up on individuals receiving bisphosphonates therapy to avoid the occurrence of osteonecrotic lesions.