Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 656204, 6 pages
http://dx.doi.org/10.5402/2011/656204
Research Article

Age-Related Success with Elective Single versus Double Blastocyst Transfer

1Stanford Fertility and Reproductive Medicine Center, Stanford University Medical Center, 900 Welch Road, Suite 350, Palo Alto, CA 94304, USA
2Seattle Reproductive Medicine, 1505 Westlake Avenue, North Suite 400, Seattle, WA 98109, USA

Received 27 August 2011; Accepted 26 September 2011

Academic Editors: E. Cosmi and A. Martin-Hidalgo

Copyright © 2011 Brooke E. Friedman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Although the optimal outcome of assisted reproductive technology (ART) is a healthy singleton pregnancy, the rate of twin gestation from ART in women over the age of 35 is persistently high. Methods/Findings. We compared clinical pregnancy rates (PRs), ongoing pregnancy/live birth rates, and multiple gestation rates (MGRs) in 108 women who chose elective single blastocyst transfer (eSBT) to 415 women who chose elective double blastocyst transfer (eDBT) at a hospital-based IVF center. There was no significant difference in PR between eSBT and eDBT (57.4% versus 50.2%, 𝑃 = 0 . 4 7 ) nor between eSBT and eDBT within each age group: <35, 35–37, 38–40, and >40. The risk of multiple gestations, however, was greatly increased between eSBT and eDBT (1.6 versus 32.4%, 𝑃 < 0 . 0 0 0 0 5 ), and this difference did not vary across age groups. Conclusion(s). Women undergoing eDBT are at uniformly high risk of multiple gestation regardless of age. eSBT appears to significantly lower the risk of multiple gestation without compromising PR.