Table of Contents
ISRN Oncology
Volume 2011, Article ID 673790, 5 pages
Clinical Study

Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer

1Division of Oncology/Hematology, Department of Medicine, Winthrop-University Hospital, 200 Old Country Road, Suite 450, Mineola, NY 11501, USA
2Division of Immunohistopathology, Department of Pathology, Winthrop-University Hospital, Mineola, NY 11501, USA
3Department of Pathology, Winthrop-University Hospital, Mineola, NY11501, USA

Received 28 March 2011; Accepted 9 May 2011

Academic Editors: Y. Haupt and G. E. Lind

Copyright © 2011 Andrei Dobrescu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To our knowledge, the hormone receptor status of noncontiguous ductal carcinoma in situ (DCIS) occurring concurrently in ER/PgR-negative invasive cancer has not been studied. The current study was undertaken to investigate the ER/PgR receptor status of DCIS of the breast in patients with ER/PgR-negative invasive breast cancer. Methods. We reviewed the immunohistochemical (IHC) staining for ER and PgR of 187 consecutive cases of ER/PgR-negative invasive breast cancers, collected from 1995 to 2002. To meet the criteria for the study, we evaluated ER/PgR expression of DCIS cancer outside of the invasive breast cancer. Results. A total of 37 cases of DCIS meeting the above criteria were identified. Of these, 16 cases (43.2%) showed positive staining for ER, PgR, or both. Conclusions. In our study of ER/PgR-negative invasive breast cancer we found that in 8% of cases noncontiguous ER/PR-positive DCIS was present. In light of this finding, it may be important for pathologists to evaluate the ER/PgR status of DCIS occurring in the presence of ER/PgR-negative invasive cancer, as this subgroup could be considered for chemoprevention.