Table of Contents
ISRN Organic Chemistry
Volume 2011, Article ID 676789, 5 pages
Research Article

An Efficient and Recyclable Ionic Liquid-Supported Proline Catalyzed Knoevenagel Condensation

1School of Chemistry and Material Science, Guizhou Normal University, Guiyang 550001, China
2College of Pharmaceutical Sciences, Zhejiang University, Zijin Compus, Hangzhou 310058, China

Received 23 January 2011; Accepted 23 February 2011

Academic Editors: D. K. Chand, F. V. Gonzalez, N. E. Leadbeater, and D. Sémeril

Copyright © 2011 Chen Zhuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Knoevenagel condensation reaction of aldehydes with malononitrile was described in this study, which was catalyzed by an efficient and recyclable ionic liquid-supported proline. The method represented an attractive alternative to the classical synthesis strategies and exhibited the advantage of performing homogeneous chemistry on a large scale additionally avoided large excesses of reagents. The products were obtained in good yields and reasonable purities without the need for further chromatographic purification. Moreover, the catalyst could be reused for at least four times.