Table of Contents
ISRN Pathology
Volume 2011, Article ID 680890, 6 pages
Research Article

Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis

1Department of Pathology, The First Affiliated Hospital, Zhengzhou University School of Medicine, Zhengzhou 450052, China
2Jdxpath Laboratory, Collegeville, PA 19426-1889, USA
3Institute of Molecular and Cell Biology, Proteos, Singapore 138673

Received 24 March 2011; Accepted 20 April 2011

Academic Editors: B. Azadeh and A. Gocht

Copyright Β© 2011 Yuqiong Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Expression of PRL-1 protein was examined with immunohistochemistry in 60 cases of esophageal squamous cell carcinoma (ESCC) with matched lymph node metastasis ( 𝑛 = 4 0 ) and 6 cases of esophageal adenocarcinoma. Its association with ESCC metastasis was also explored. The results showed that PRL-1 protein was more frequently expressed in ESCC with metastasis (31/40, 77.5%) than in ESCC without metastasis (10/20, 50%, 𝑃 = . 0 3 1 ) and more in metastatic ESCC (39/40, 97.5%) than primary ESCC (68.3%, 𝑃 = . 0 0 3 ) . PRL-1 protein expression significantly correlated with the stage of ESCC, 79.4% (27/34) in stage III ESCC and 33.3% (1/3) in stage 1 ESCC ( 𝑃 = . 0 0 3 ) . PRL-1 protein was characteristically expressed in the nuclei, in addition to the cytoplasm, of 3 out of 4 (66.7%) poorly differentiated esophageal adenocarcinoma. These findings suggest that PRL-1 may serve as the potential biomarker to predict the metastasis of ESCC and a better biomarker than PRL-3 in the differential diagnosis of poorly differentiated ESCC.