Table of Contents
ISRN Pediatrics
Volume 2011, Article ID 707206, 9 pages
http://dx.doi.org/10.5402/2011/707206
Research Article

High-Sensitivity C Reactive Protein: Associations with Cardiovascular Risk Factors and Tracking in Female Adolescents and Young Adults

1Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
2Cholesterol Center, Jewish Hospital of Cincinnati-Mercy Health Partners, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
3Children's Hospital, Denver, CO 80045, USA
4Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
5Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221, USA
6Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, OH 45220, USA

Received 24 November 2010; Accepted 30 December 2010

Academic Editors: C. D. Berkowitz and S. A. Sarker

Copyright Β© 2011 John A. Morrison et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ ( 𝑃 > . 0 8 ) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 ( π‘Ÿ = 0 . 7 7 ), 16 to 26 ( π‘Ÿ = 0 . 5 0 ), 24 to 26 ( π‘Ÿ = 0 . 6 6 ), and 25 to 26 ( π‘Ÿ = 0 . 7 1 ), all 𝑃 ≀ . 0 2 . By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, 𝑃 < . 0 0 0 1 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24–26 (partial 𝑅 2 = 1 2 . 3 %   𝑃 < . 0 0 0 1 , 6.6%   𝑃 = . 0 0 1 2 ). Changes in BMI and triglyceride (partial 𝑅 2 = 8 . 5 %   𝑃 = . 0 0 0 1 , 3.3%, 𝑃 = . 0 0 4 5 ) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.