Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 712196, 4 pages
Research Article

Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as “Support for Normal Blood Pressure”

1Division of Medical and Pharmaceutical Sciences-II, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1, Kaga, Itabashi, Tokyo 173-8605, Japan
2Division of Medical and Pharmaceutical Sciences-I, Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1, Suarashi, Midori, Sagamihara, Kanagawa 252-0195, Japan

Received 23 April 2011; Accepted 18 June 2011

Academic Editors: A. N. Assimopoulou, A. Bolognese, J.-J. Chen, and S. Vincent

Copyright © 2011 Isao Murakami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The ACE inhibitory activities of mixtures of FOSHUs (Healthya, Goma-Mugicha, Lapis Support and Ameal) were examined in order to identify any antihypertensive interactions. Among combinations of Healthya with other samples that contain active peptides, only that with Ameal was found to have no inhibitory activity. Enhanced activity was observed in 2 other mixtures. The activity of a mixture of tea polyphenols and the whey component extracted from an Ameal solution was significantly decreased, thus demonstrating that whey protein lowered the ACE inhibitory activity of Healthya. Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with Ameal failed to decrease SBP at the same time points. In conclusion, the simultaneous intake of tea and FOSHUs that contain active peptides might affect daily self-antihypertensive management via enhancement or suppression of ACE inhibitory activity.