Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte 𝛼^{𝟔𝟖Asn→Lys}_𝟐𝛽^{𝟔𝟐Ala→Pro}_𝟐)

Figure 7

Pictorial view of the alpha globin chains superimposed after 6 and 8 ns of MD simulations. (Blue tube) double variant and (orange tube) HbA. In yellow the amino acids of the CD corner pointing the distal histidine. In green the Glu64 at position E13, in violet Ala79 at position EF8, and in orange and blue the residue at position E17, respectively, Lys and Asn, for the two systems.