Table of Contents
ISRN Microbiology
Volume 2011, Article ID 745868, 4 pages
Research Article

Diphtheria, Tetanus, and Pertussis Immunity in Indian Adults and Immunogenicity of Td Vaccine

1Clinical Department, Serum Institute of India Ltd., 212/2, Hadapsar, Pune 411028, India
2Medical Department, Serum Institute of India Research Foundation, Pune 411028, India
3Quality Control Department, Serum Institute of India Ltd., 212/2, Hadapsar, Pune 411028, India

Received 10 October 2011; Accepted 13 November 2011

Academic Editors: H. I. Atabay and X. Yu

Copyright © 2011 Prasad S. Kulkarni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Rise of diphtheria cases in adults is a cause of concern worldwide. Pertussis is also now affecting adults. We assessed serum levels of tetanus, diphtheria and pertussis antibodies in 62 adults in Pune, India, who had missed their primary immunization. All adults were then given three doses of tetanus-diphtheria (Td) vaccine at 0, 1, and 6 months. All adults were immune to tetanus but 78% had long-term protection. For diphtheria, 88% were protected but only 9% had long term immunity. Only 60% were immune to pertussis. After three doses of the vaccine, long term immunity to both tetanus and diphtheria increased to 87% and 97%, respectively ( 𝑃 < 0 . 0 5 ). Geometric mean titres (GMT) of both antibodies also increased significantly. The vaccine caused minor local reactions and mild fever in a few subjects. There is need of three doses of Td vaccination in those Indian adults, who missed their primary immunization. Susceptibility to pertussis also needs to be further explored.