Table of Contents
ISRN Veterinary Science
Volume 2011 (2011), Article ID 749753, 7 pages
http://dx.doi.org/10.5402/2011/749753
Research Article

Modulating Effect of Ascorbic Acid on Transport-Induced Immunosuppression in Goats

1College of Agriculture and Animal Science, Division of Agricultural Colleges, P.M.B. 2134, Ahmadu Bello University, Mando, Kaduna, Nigeria
2Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria 810261, Nigeria

Received 30 January 2011; Accepted 6 March 2011

Academic Editors: K. Borchers and P. Holt

Copyright © 2011 Ndazo Salka Minka and Joseph Olusegun Ayo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of 12 h road transportation on some basic blood cells and the modulating role of ascorbic acid were investigated in 40 adult Red Sokoto goats during the hot dry season. The animals were divided into two groups, GI (experimental; 𝑛 = 2 0 ) and GII (control; 𝑛 = 2 0 ). Group 1 was administered with ascorbic acid (AA) per os at a dosage rate of 100 mg/kg body weight, while GII was given 10 mL of sterile water per goat. Forty minutes after the administration and loading, the goats were transported for 12 h. The result obtained in GII goats showed that loading, transportation, high ambient temperature (AT), and relative humidity (RH) encountered during transportation induced lymphopenia, neutrophilia, and eosinopenia, which can cause immunosuppression. In GI goats, the administration of AA prior to loading and transportation ameliorated the adverse effects of loading and transportation stress on neutrophil/lymphocyte ratio and eosinopenia of the goats.