Table of Contents
ISRN Cardiology
Volume 2011, Article ID 750301, 6 pages
http://dx.doi.org/10.5402/2011/750301
Research Article

Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs

1Laboratory of Hemodynamic and Cardiovascular Mechanisms, and Departments of Intensive Care, AP-HM, 13385 Marseille Cedex 05, France
2UMR MD2 P2COE, Université de la Méditerranée, Faculté de Médecine, 13385 Marseille Cedex 05, France
3Department of Cardiac Surgery, AP-HM, 13385 Marseille Cedex 05, France
4Free University of Brussels, B-1070 Brussels, Belgium
5Laboratory of Biochemistry, Timone Hospital, AP-HM, 13385 Marseille Cedex 05, France

Received 14 February 2011; Accepted 30 March 2011

Academic Editors: P. S. Gutierrez and M. Saeed

Copyright © 2011 François Kerbaul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adenosine plays a role in pulmonary arterial (PA) resistance due to its vasodilator properties. However, the behavior of adenosine plasma levels (APLs) during pulmonary embolism remains unknown. We investigated the effects of gradual pulmonary embolism on right ventricular (RV) contractility and PA coupling and on APLs in an piglet experimental model of RV failure. PA distal resistance by pressure-flow relationships and pulmonary vascular impedance were measured. RV contractility was determined by the end-systolic pressure-volume relationship (Ees), PA effective elastance by the end-diastolic to end-systolic relationship (Ea), and RV-PA coupling efficiency by the Ees/Ea ratio. APLs were measured before and during gradual pulmonary embolization. PA embolism increased PA resistance and elastance, increased Ea from 1 . 0 8 ± 0 . 1 5 to 5 . 6 2 ± 0 . 3 2  mmHg/mL, decreased Ees from 1 . 8 2 ± 0 . 1 0 to 1 . 2 0 ± 0 . 2 3  mmHg/mL, and decreased Ees/Ea from 1 . 6 9 ± 0 . 1 5 to 0 . 2 1 ± 0 . 0 7 . APLs decreased from 2 . 7 ± 0 . 2 6 to 1 . 3 ± 0 . 1 2 μM in the systemic bed and from 4 . 0 3 ± 0 . 6 3 to 2 . 5 1 ± 0 . 5 8 μM in the pulmonary bed during embolism procedure. Pulmonary embolism worsens PA hemodynamics and RV-PA coupling. APLs were reduced, both in the systemic and in the pulmonary bed, leading then to pulmonary vasoconstriction.