Table of Contents
ISRN Gastroenterology
Volume 2011, Article ID 756292, 9 pages
http://dx.doi.org/10.5402/2011/756292
Research Article

Diagnosis and Therapy of Microscopic Colitis with Presence of Foamy Macrophages in Children

1Pediatric Ward, Hospital in Sandomierz, Schinzla 13, 27-600 Sandomierz, Poland
2Department of Pathology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland

Received 12 April 2011; Accepted 4 May 2011

Academic Editor: C.-Y. Chen

Copyright © 2011 Jan Józefczuk and Bogdan Marian Woźniewicz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification. No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease. The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition. Use of magnesium caused a histological, statistically significant improvement but failed to have any effect on the clinical and endoscopic presentation. In the group of children in whom no therapeutic intervention was provided, a statistically significant spontaneous clinical improvement was observed, but no statistically significant changes in endoscopic and microscopic condition were found.