Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats

Table 1

	Time	LETO	OLETF normal diet	OLETF high sucrose	OLETF high fat	OLETF calorie restriction
BW (g)	Baseline	193 ± 3	247 ± 7*	224 ± 4*	216 ± 5*	234 ± 5*
	13 w	393 ± 10	511 ± 14*	524 ± 9*	587 ± 14^*#	441 ± 6^*#
	27 w	486 ± 17	689 ± 19*	702 ± 15*	705 ± 20*	639 ± 8^*#
Fat weight/BW	13 w	0.012 ± 0.001	0.017 ± 0.001*	0.026 ± 0.001^*#	0.038 ± 0.001^*#	0.011 ± 0.001
	27 w	0.014 ± 0.001	0.022 ± 0.001*	0.027 ± 0.001^*#	0.028 ± 0.001^*#	0.021 ± 0.001*
Blood glucose (postprandial; mg/dL)	Baseline	98 ± 2	118 ± 5	117 ± 6	123 ± 6	113 ± 6
	13 w	126 ± 2	198 ± 16*	207 ± 17*	218 ± 15*	141 ± 5^#
	27 w	141 ± 4	265 ± 20*	262 ± 15*	249 ± 24*	229 ± 25*
Blood glucose (fasting; mg/dL)	13 w	84 ± 4	88 ± 4	122 ± 8^*#	133 ± 6^*#	96 ± 4
	27 w	94 ± 6	112 ± 7	106 ± 6	109 ± 8	113 ± 8
Insulin (fasting; ng/mL)	13 w	0.7 ± 0.2	1.2 ± 0.2	3.4 ± 0.2^*#	6.2 ± 0.9^*#	1.2 ± 0.3
	27 w	1.9 ± 0.3	5.3 ± 0.4*	5.3 ± 0.5*	6.5 ± 0.6*	5.7 ± 0.5*

^∗𝑃<0.05 versus LETO rats, ^#𝑃<0.05 versus normal-diet-fed OLETF rats.