Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 780150, 7 pages
http://dx.doi.org/10.5402/2011/780150
Research Article

Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin

1Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, West Bengal, Durgapur 713212, India
2Department of Pharmaceutics, Gupta College of Technological Sciences, West Bengal, Asansol 713301, India
3Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Orissa, Mayurbhanj 757086, India

Received 5 April 2011; Accepted 16 May 2011

Academic Editors: C. V. Garcia, K. Pudhom, and C. Ferrero Rodríguez

Copyright © 2011 Jadupati Malakar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Peltola, P. Saarinen-Savolainen, J. Kiesvaara, T. M. Suhonen, and A. Urtti, “Microemulsions for topical delivery of estradiol,” International Journal of Pharmaceutics, vol. 254, no. 2, pp. 99–107, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Yuel, L. San-ming, Y. Li-min, D. Pan, and Z. Da-fangl, “Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam,” Chemical Research in Chinese Universities, vol. 23, no. l, pp. 81–86, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. R. Gasco, “Microemulsions in the pharmaceutical field: perspectives and applications,” in Industrial Applications of Microemulsions, pp. 97–122, Marcel Dekker, New York, NY, USA, 1997. View at Google Scholar
  4. A. C. Sintov and S. Botner, “Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems,” International Journal of Pharmaceutics, vol. 311, no. 1–2, pp. 55–62, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. M. El Maghraby, “Self-microemulsifying and microemulsion systems for transdermal delivery of indomethacin: effect of phase transition,” Colloids and Surfaces, vol. 75, no. 2, pp. 595–600, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Baroli, M. A. López-Quintela, M. B. Delgado-Charro, A. M. Fadda, and J. Blanco-Méndez, “Microemulsions for topical delivery of 8-methoxsalen,” Journal of Controlled Release, vol. 69, no. 1, pp. 209–218, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. M. B. Delgado-Charro, G. Iglesias-Vilas, J. Blanco-Méndez, M. A. López-Quintela, J. P. Marty, and R. H. Guy, “Delivery of a hydrophilic solute through the skin from novel microemulsion systems,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 43, no. 1, pp. 37–42, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Kreilgaard, “Influence of microemulsions on cutaneous drug delivery,” Advanced Drug Delivery Reviews, vol. 54, pp. S77–S98, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. G. M. El Maghraby, “Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants,” International Journal of Pharmaceutics, vol. 355, no. 1–2, pp. 285–292, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Hermeling, D. J. A. Crommelin, H. Schellekens, and W. Jiskoot, “Structure-immunogenicity relationships of therapeutic proteins,” Pharmaceutical Research, vol. 21, no. 6, pp. 897–903, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. K. Nayak, “Advances in therapeutic protein production and delivery,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 2, no. 2, pp. 1–5, 2010. View at Google Scholar · View at Scopus
  12. K. D. Tripathi, “Insulin, oral hypoglycaemics and glucagon,” in Essentials of Medical Pharmacology, chapter 18, pp. 264–283, Jaypee Brothers Medical Publishers, New Delhi, India, 4th edition, 1999. View at Google Scholar
  13. S. N. Davis, “Insulin, oral hypoglycemic agents, and the pharmacology of endocrine pancreas,” in Goodman and Gilman's the Pharmacological Basis of Therapeutics, L. L. Brunton, J. S. Lazo, and K. L. Parker, Eds., pp. 1613–1616, McGraw-Hill, New York, NY, USA, 11th edition, 2005. View at Google Scholar
  14. D. Shah, V. Agarawal, and R. Parikh, “Non invasive insulin delivery system: a review,” International Journal of Applied Pharmaceutics, vol. 2, no. 1, pp. 35–40, 2010. View at Google Scholar
  15. E. S. Khafagy, M. Morishita, Y. Onuki, and K. Takayama, “Current challenges in non-invasive insulin delivery systems: a comparative review,” Advanced Drug Delivery Reviews, vol. 59, no. 15, pp. 1521–1546, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. F. P. Kennedy, “Recent developments in insulin delivery techniques: current status and future potential,” Drugs, vol. 42, no. 2, pp. 213–227, 1991. View at Google Scholar · View at Scopus
  17. A. Sen, M. E. Daly, and S. W. Hui, “Transdermal insulin delivery using lipid enhanced electroporation,” Biochimica et Biophysica Acta, vol. 1564, no. 1, pp. 5–8, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Pillai, V. Nair, and R. Panchagnula, “Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers,” International Journal of Pharmaceutics, vol. 269, no. 1, pp. 109–120, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. O. Pillai, V. Nair, N. Sivaprasad, and R. Panchagnula, “Transdermal iontophoresis of insulin: II. Physicochemical considerations,” International Journal of Pharmaceutics, vol. 254, no. 2, pp. 271–280, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. C. S. Amnon and U. Wormser, “Topical iodine facilitates transdermal delivery of insulin,” Journal of Controlled Release, vol. 118, no. 2, pp. 185–188, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Cevc, “Transdermal drug delivery of insulin with ultradeformable carriers,” Clinical Pharmacokinetics, vol. 42, no. 5, pp. 461–474, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. M. J. King, I. Badea, J. Solomon, P. Kumar, K. J. Gaspar, and M. Foldvari, “Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats,” Diabetes Technology and Therapeutics, vol. 4, no. 4, pp. 479–488, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. J. H. Yang, Y. I. Kim, and K. M. Kim, “Preparation and evaluation of aceclofenac microemulsion for transdermal delivery system,” Archives of Pharmacal Research, vol. 25, no. 4, pp. 534–540, 2002. View at Google Scholar · View at Scopus
  24. D. V. Derle, B. S. H. Sagar, and P. Sagar, “Microemulsion as a vehicle for transdermal permeation of nimesulide,” Indian Journal of Pharmaceutical Sciences, vol. 68, no. 5, pp. 622–625, 2006. View at Google Scholar · View at Scopus
  25. O. Pillai and R. Panchagnula, “Transdermal iontophoresis of insulin: VI. Influence of pretreatment with fatty acids on permeation across rat skin,” Skin Pharmacology and Physiology, vol. 17, no. 6, pp. 289–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. B. W. Barry, Dermatological Formulations: Percutaneous Absorption, Marcel Dekker, New York, NY, USA, 1983.
  27. R. Gannu, V. Vishnu Yamsani, and M. Rao Yamsani, “Enhancement potential of Aloe vera on permeation of drugs with diverse lipophilicities across rat abdominal skin,” Current Trends in Biotechnology and Pharmacy, vol. 2, no. 4, pp. 548–554, 2008. View at Google Scholar
  28. A. K. Nayak, B. Mohanty, and K. K. Sen, “Comparative evaluation of in vitro diclofenac sodium permeability across excised mouse skin from different common pharmaceutical vehicles,” International Journal of PharmTech Research, vol. 2, no. 1, pp. 920–930, 2010. View at Google Scholar · View at Scopus
  29. V. M. Patel, B. G. Prajapati, and M. M. Patel, “Effect of hydrophilic polymers on buccoadhesive Eudragit patches of propranolol hydrochloride using factorial design,” AAPS PharmSciTech, vol. 8, no. 2, article 45, 2007. View at Google Scholar · View at Scopus
  30. I. B. Pathan and C. M. Setty, “Chemical penetration enhancers for transdermal drug delivery systems,” Tropical Journal of Pharmaceutical Research, vol. 8, no. 2, pp. 173–179, 2009. View at Google Scholar · View at Scopus
  31. B. Idson, “Hydration and percutaneous absorption,” Current Problems in Dermatology, vol. 7, pp. 132–137, 1978. View at Google Scholar · View at Scopus
  32. B. W. Barry, “Mode of action of penetration enhancers in human skin,” Journal of Controlled Release, vol. 6, pp. 85–91, 1987. View at Google Scholar · View at Scopus
  33. S. K. Chandrasekaran, P. S. Champbell, and A. S. Michels, “Effects of dimethylsulfoxide on drug permeation through human skin,” AIChE Journal, vol. 23, no. 6, pp. 810–816, 1977. View at Google Scholar
  34. G. Embery and P. H. Dugard, “The isolation of dimethylsulphoxide soluble components from human epidermal preparation: a possible mechanism of action of dimethylsulphoxide in affecting percutaneous migration phenomena,” Journal of Investigative Dermatology, vol. 57, no. 5, pp. 308–311, 1971. View at Google Scholar