The Contribution of Four Immunogenetic Markers for Predicting Persistent Activity in Patients with Recent-Onset Rheumatoid Arthritis or Undifferentiated Arthritis

Table 2

Univariate analyses to identify predictors of a disease activity score (DAS28) ≥ 2.6 at one year.

Variables^a	DAS28 < 2.6 𝑁=57^b	DAS28 ≥ 2.6 𝑁=144^b	𝑃 value
Anti-CCP: 𝑛 (%)
Positive	19 (33.3)	69 (47.9)	0.060
Negative	38 (66.7)	75 (52.1)
Anti-CCP: mean (SD)	46.7 (81.2)	76.9 (102.7)	0.030
RF: 𝑛 (%)
Positive	22 (38.6)	63 (43.7)	0.167
Negative	35 (61.4))	81 (56.3)
RF: mean (SD)	127.3 (233.8)	140.8 (298.9)	0.759
SE: 𝑛 (%)
−/−	46 (80.7)	70 (48.6)	< 0.001
−/+	8 (14.0)	61 (42.4)
+/+	3 (5.3)	13 (9.0)
−308 TNFα: 𝑛 (%)
GG	42 (76.4)	113 (81.3)	0.443
GA/AA	13 (23.6)	26 (18.7)
Classification criteria
1987 ARA criteria for RA	31 (54.4)	111 (77.1)	0.002
UA	26 (45.6)	33 (22.9)
DMARD: 𝑛 (%)
Yes	45 (78.9)	136 (94.4)	0.003
No	12 (21.1)	8 (5.6)
Number of DMARD: mean (SD)	1.16 (0.774)	1.74 (0.826)	<0.001
Corticosteroids: 𝑛 (%)
Yes	53 (93.0)	132 (91.7)	0.756
No	4 (7.0)	12 (8.3)

^aAll variables measured at baseline, except ARA criteria for RA and treatments.
^bExcept for –308 TNFα, where 7 cases (2 with DAS28 < 2.6, and 5 with DAS28 ≥ 2.6) could not be genotyped.
Abbreviations: Anti-CCP: anticyclic citrullinated peptide antibodies. SD: standard deviation. RF: rheumatoid factor. SE: shared epitope. −308 TNFα: G-to-A polymorphism at position 308 of the TNFα gene promoter. ARA: American Rheumatism Association. RA: rheumatoid arthritis. UA: undifferentiated arthritis. DMARD: disease-modifying antirheumatic drugs.