Table of Contents
ISRN Microbiology
Volume 2011, Article ID 787290, 5 pages
http://dx.doi.org/10.5402/2011/787290
Research Article

Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability

1R.M. Alden Research Laboratory, Culver City, CA 90230, USA
2Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA

Received 23 August 2011; Accepted 28 September 2011

Academic Editor: P. D. Ghiringhelli

Copyright © 2011 Diane M. Citron et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 106 CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains.