Table of Contents
ISRN Neurology
Volume 2011, Article ID 805646, 6 pages
Review Article

Targeting Fatigue in Stroke Patients

1Division of Medicine, Royal Sussex County Hospital, Brighton, East Sussex BN2 5BE, UK
2Kent Community Health NHS Trust, Ashford, Kent TN24 5AZ, UK

Received 13 September 2011; Accepted 9 October 2011

Academic Editors: A. Arboix and A. Conti

Copyright © 2011 Andrew W. Barritt and David G. Smithard. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Symptoms of fatigue are often reported by patients in both the acute and chronic stages of recovery following a stroke. It is commonly associated with low mood and sleep disturbances, but can arise in their absence. However, it has also been associated with poorer long-term outcome and, as such, its aetiology warrants a greater understanding. There is convincing evidence that inflammatory cascades and cytokine signalling precipitated by the infarct promote fatigue, and these pathways may harbour therapeutic targets in its management.