Table of Contents
ISRN Cardiology
Volume 2011, Article ID 816025, 4 pages
http://dx.doi.org/10.5402/2011/816025
Research Article

Association of PPAR ๐œถ Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study

1Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 011, India
2Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 011, India

Received 14 February 2011; Accepted 13 March 2011

Academic Editor: E. Liberopoulos

Copyright ยฉ 2011 Sreeja Purushothaman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The allelic variants of peroxisome proliferator-activated receptor alpha (PPARα) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARα intronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD ( O R = 2 . 9 ; 95% CI [1.65–4.145]; ๐‘ƒ = . 0 0 9 ) and also with dyslipidaemia ( O R = 2 . 9 5 , 95% CI (1.5–4.39); ๐‘ƒ < . 0 5 ). Impaired lipid metabolism in carriers of the PPARα Intron 7C allele is possibly responsible for the predilection to CAD.