Research Article
Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers
Figure 5
(a) Comparative in vitro dissolution profiles of etoricoxib solid dispersions using lactose [SD-L (1 : 1), SD-L (1 : 5)], etoricoxib-lactose physical mixtures [PM-L (1 : 1), PM-L (1 : 5)], and pure etoricoxib [ET] (Mean ± SD, n = 3). (b) Comparative in vitro dissolution profiles of etoricoxib solid dispersions using sucrose [SD-S (1 : 1), SD-S (1 : 5)], etoricoxib-sucrose physical mixtures [PM-S (1 : 1), PM-S (1 : 5)] and pure etoricoxib [ET] (Mean ± SD, n = 3). (c) Comparative in vitro dissolution profiles of etoricoxib solid dispersions using mannitol [SD-M (1 : 1), SD-M (1 : 5)], etoricoxib-mannitol physical mixtures [PM-M (1 : 1), PM-M (1 : 5)], and pure etoricoxib [ET] (Mean ± SD, n = 3). (d) Comparative in vitro dissolution profiles of etoricoxib solid dispersions using lactose [SD-L (1 : 5)], sucrose [SD-S (1 : 5), and mannitol [SD-M (1 : 5)], and pure etoricoxib [ET] (Mean ± SD, n = 3).
