Research Article

Modification of a Volume-Overload Heart Failure Model to Track Myocardial Remodeling and Device-Related Reverse Remodeling

Figure 2

(a) Biopsy specimen obtained at left ventricular assist device (LVAD) implantation, showing a loss of myofilaments in the perinuclear region (asterisk) and the presence of cytoplasmic vacuoles (arrows). (b) Biopsy specimen obtained after 11 weeks of LVAD unloading, showing a reduced loss of myofilaments, with fewer and smaller cytoplasmic vacuoles (arrow) and more and larger mitochondria (dagger). Magnification ×2500; scale bar 2 μM.