Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Table 2

Log10 transformed allergen stimulation minus medium stimulation at day 1: baseline versus postbaseline cytokine production levels.

		Log10 (allergen stimulation minus medium stimulation) at baseline (range)	Log10 (allergen stimulation minus medium stimulation) at postbaseline (range)	Mean difference (95% CI)
Gencydo	IL-10^#	1.91 (1.16–2.39)	1.85 (1.23–2.51)	ns
	IFN-γ	0.07 (0.01–0.34)	0.03 (0.1–0.28)	ns
	TNF-α	1.60 (1.16–2.12)	1.09 (0.25–2.08)	−.50* (−0.08 to −0.93)
Citrus/Cydonia	IL-10	1.64 (0.66–2.25)	1.60 (0.95–2.12)	ns
	IFN-γ	0.09 (0.1–0.50)	0.15 (0.1–0.84)	ns
	TNF-α	1.20 (−1.10–2.23)	1.34 (0.29–2.18)	ns
Total group	IL-10	1.77 (0.66–2.39)	1.73 (0.95–2.51)	ns
	IFN-γ	0.08 (0.1–0.50)	0.09 (0.1–0.84)	ns
	TNF-α	1.40 (−1.10–2.23)	1.21(0.25–2.18)	ns

* P value <.05.