Research Article

Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix

Table 3

Rate constants* of photodegradation for ITN in methanol solution and microemulsion ( 𝑛 = 3 ).

DrugSample matrixK 𝑡 0 . 5 𝑅 2

ITNMethanol solution 8 . 0 6 × 1 0 3 860.9830
Microemulsion 1 . 8 4 × 1 0 3 3770.9899
formulation

𝑡 is expressed in minutes.