International Scholarly Research Notices / 2011 / Article / Tab 3

Clinical Study

A Comprehensive Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

Table 3

Changes of Actigraph, MMSE, HAM-D, WAIS-R, cerebral blood flow, and cerebrospinal fluid by rTMS (sham and real).

Before rTMSAfter sham rTMSAfter real rTMS 𝑃 value

Actigraph up state (1)Mean counts per one minute 1 3 1 . 2 ± 1 7 . 0 1 3 1 . 4 ± 2 7 . 2 1 3 0 . 1 ± 3 1 . 7 0.977
Resting (%) 1 7 . 1 ± 4 . 5 1 8 . 9 ± 7 . 2 1 9 . 0 ± 8 . 6 0.611
Actigraph down state (2)Mean counts per one minute 3 1 . 0 ± 2 4 . 4 3 1 . 0 ± 1 9 . 6 3 5 . 2 ± 2 6 . 8 0.652
Resting (%) 8 0 . 8 ± 1 7 . 5 7 6 . 7 ± 1 5 . 2 7 5 . 9 ± 1 5 . 9 0.593

MMSE 2 5 . 3 3 ± 3 . 0 3 2 5 . 4 2 ± 2 . 9 7 2 6 . 5 8 ± 2 . 9 7 0.114
HAM-D 1 1 . 2 5 ± 6 . 3 0 1 0 . 3 3 ± 4 . 9 1 9 . 4 2 ± 4 . 3 2 0.447

WAIS-R#Verbal IQ 9 7 . 3 0 ± 2 0 . 6 3 1 0 1 . 6 3 ± 1 8 . 6 2 9 8 . 8 0 ± 2 0 . 8 0 0.901
Performance IQ 8 9 . 6 0 ± 1 0 . 4 5 9 6 . 0 0 ± 9 . 4 1 9 9 . 8 0 ± 9 . 3 6 0.159
Total IQ 9 3 . 4 0 ± 1 6 . 7 8 9 9 . 0 0 ± 1 4 . 6 8 9 8 . 0 0 ± 1 6 . 9 3 0.742

Cerebral blood flow(ml/min/100 g) 4 7 . 5 0 ± 3 . 2 6 4 5 . 7 5 ± 3 . 5 5 4 7 . 7 5 ± 3 . 9 6 0.078

Cerebrospinal fluid##Total protein (mg/dl) 4 1 . 2 ± 1 3 . 1 3 9 . 9 ± 1 4 . 7 0.579
HVA (ng/ml) 3 5 . 3 ± 1 7 . 9 3 6 . 2 ± 1 2 . 8 0.817
5-HIAA (ng/ml) 1 3 . 4 ± 7 . 7 1 3 . 7 ± 7 . 6 0.799
MHPG (ng/ml) 9 . 5 ± 2 . 9 9 . 0 ± 2 . 5 0.368
NSE (ng/ml) 1 5 . 5 ± 9 . 2 1 5 . 4 ± 7 . 6 0.952

Repeated measures ANOVA, * 𝑃 < 0 . 0 5 . #One-way ANOVA. ##Paired 𝑡 -test. (1): Actigraph record while awaken. (2): Actigraph record while sleeping. MMSE: Mini-Mental State Examination, HAM-D: Hamilton Depression Scale. WAIS-R: Wechsler Adult Intelligence Scale-Revised, IQ: intellectual quotient. HVA: homovanillic acid; 5-HIAA: 5-hydroxy indoleacetic acid; MHPG: 3-methoxy-4-hydroxyphenylethylene glycol. NSE: neuron-specific enolase.