Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats

Table 2

Effect of various extracts of H. indicum leaves on percentage (%) wound closure (excision wound model).

Group	Treatment	Percentage (%) wound closure						Period of epithelialization (No. of days)
		4th days	6th days	8th days	11th days	14th days	16th days
I	Control	23.52 ± 1.21	37.72 ± 1.58	51.92 ± 1.71	71.28 ± 2.23	79.24 ± 1.18	83.56 ± 1.03	23.16 ± 0.71
II	Nitrofurazone (0.2% w/w)	48.53 ± 2.87*	74.23 ± 3.32**	84.8 ± 1.26**	96.54 ± 1.29**	100 ± 00**	—	13.5 ± 1.54**
III	Pet ether extract	22.15 ± 1.75	38.73 ± 2.16	44.70 ± 3.25	70.58 ± 1.88	79.69 ± 1.22	83.88 ± 2.01	20.5 ± 1.33
IV	Chloroform extract	24.19 ± 1.03	44.41 ± 1.22	61.88 ± 1.83	75.68 ± 2.31	81.26 ± 1.65	85.80 ± 1.43	19. ± 0.91*
V	Methanol extract	28.88 ± 1.95	48.34 ± 1.86*	79.78 ± 1.91*	86.37 ± 1.01**	97.76 ± 2.22**	100 ± 00**	16.23 ± 0.98**
VI	Aqueous Extract	29.23 ± 1.65	48.01 ± 2.01*	65.28 ± 2.83*	77.25 ± 1.11*	90.42 ± 1.71**	93.7 ± 1.22	18.5 ± 0.77*

Values are expressed as mean ± S.E. (𝑛=6). All columns are significant using ANOVA.
* 𝑃<.05,** 𝑃<.01 when compared to control; Dunnet’s 𝑡-test.