| | Author year (Ref) | Study type | Study dates | Single-center or multicenter | No. of pts | Patient characteristics | | Mean age ± SD (range) (yrs) | Gender | Mean followup (mos) | Primary site of malignancy (% no. of pts) | | M (no.) | F (no.) |
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Schnoll et al. 2003 [4] | RCT | NR | Single | 74 | 57 ± 11.4 | 38 | 36 | 3 | Lung (69), Head and Neck (31) | |
Wakefield et al. 2004 [11] | RCT | 2002–2008 | Single | 246 | 54.8 ± NR | 128 | 118 | 6 | Lung or Head and Neck (32.2), Breast (21), Prostate (15), Lymphoma (9), Colorectal (5), Kidney, pancreas, liver (4), GU (3), Esophageal (3), Other or multiple primaries (5) | |
Gritz et al. 2006 [12] | RCT | 1999–2001 | Single | 137 | I: 52.6 ± 13.8, U: 51.9 ± 11.5 | 85 | 52 | 6 | Lung (12), Head and neck (17), Bladder (2), Breast (13), Prostate (9), Colorectal (10), Leukemia (10), Lymphoma (15), Testicle (4), Other (8) | |
Wewers et al. 1994 [13] | RCT | 2000–2003 | Multi (4 hospitals) | 184 | 57 ± 9.9 | 155 | 29 | 6 | Head and Neck: larynx (33), oropharynx/hypopharynx (30), oral cavity/other (37) | |
Gritz et al. 1993 [1] | RCT | NR | Multi (10 clinics) | 186 | C: 57.8 ± 9.5, NC: 59.5 ± 9.5 | 137 | 49 | 12 | C: buccal cavity 59(52.7%), pharynx 6 (5.4%), larynx 47 (42.0%); NC: buccal cavity 58.3 (42%), pharynx 5 (6.9%), larynx 25 (34.7%) | |
Rothman and Greenland 1998 [15] | RCT | NR | Single | 30 | I: 56.4 ± 13.6, U: 53.2 ± 13.3 | 10 | 20 | 5 weeks | Heak and Neck (83.3), Breast cancer (6.7), Prostate cancer (6.7), Cervical cancer (3.3) | |
Greenland and Robins 1985 [16] | RCT | NR | Single | 28 | I: 50.2 ± 12.4,
U: 51.9 I: 50.2 ± 10.5 | 14 | 16 | 1.5 | Gynecologic (6.21), Breast (5.18), Gastrointestinal (4.14), Thoracic (4.14), Urologic (4.14), Neurologic (4.14), Head and Neck (2.7) | |
Griebel et al. 1998 [17] | RCT | NR | Single | 109 | I: 58.7 ± 9,
U: 57.7 ± 10.1 | 59 | 50 | 1 and 3 | Head and Neck (69), Lung (31) |
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F, female; I, intervention; M, male; mos, months; no., number; NR, not reported; NS, not significant; pts, patients; ref, reference; U, usual care; yrs, years, C: completers, NC: non-completers.
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