Table of Contents
ISRN Pharmacology
Volume 2011 (2011), Article ID 851870, 8 pages
http://dx.doi.org/10.5402/2011/851870
Research Article

Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism

Centre for Human Metabonomics, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom 2522, South Africa

Received 30 November 2010; Accepted 13 January 2011

Academic Editors: J. C. Laguna and A. Zhang

Copyright © 2011 Catharina M. C. Mels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acetylsalicylic acid and/or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function. These effects include both inhibitory and stimulatory effects. We investigated the effect of both combined and separate oral acetylsalicylic acid and acetaminophen administration at therapeutic doses on the urinary metabolite profile of human subjects. In this paper, we provided in vivo evidence, in human subjects, of a statistically significant increase in isobutyrylcarnitine after the administration of a therapeutic dose of acetylsalicylic acid. We, therefore, propose an inhibitory effect of acetylsalicylic acid on the short-chain fatty acid metabolism, possibly at the level of isobutyryl-CoA dehydrogenase.