Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism

<table>Proposed inhibition by salicylic acid of the branched-chain amino acid catabolism.  Inhibition (or deficiency) of (1) isovaleryl-CoA dehydrogenase, (2) 2-methylbutyryl-CoA dehydrogenase, and (3) isobutyryl-CoA dehydrogenase, will result in the accumulation of C4-carnitine and C5-carnitine species.</table>

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Figure 1

Figure 1: Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism 

Figure 1 | Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism 