International Scholarly Research Notices

Research Article

Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism

Table 1

Paired 𝑡 -test values ( 𝑃 -values) of acylcarnitine species in baseline urine samples compared to acylcarnitine species in urine samples obtained after acetylsalicylic acid administration ( 𝑛 = 7 ), acetaminophen administration ( 𝑛 = 7 ), and combined administration of both acetylsalicylic acid and acetaminophen ( 𝑛 = 3 0 ).
Acylcarnitine speciesPaired 𝑡 -test ( 𝑃 -value)
Acetylsalicylic acid administration ( 𝑛 = 7 )Acetaminophen administration ( 𝑛 = 7 )Combined administration ( 𝑛 = 3 0 )
C0-carnitine0.180.200.72
C2-carnitine0.080.060.87
C3-carnitine0.960.880.05*
C4-carnitine 0.03*0.310.00*
C4-OH-carnitine0.180.120.32
C4-DC-carnitine0.160.05*0.08
C5-carnitine0.730.850.00*
C5-OH-carnitine0.690.330.35
C5-DC/C10-OH-carnitine0.170.01*0.26
C5 : 1-carnitine0.240.500.29
C6-carnitine0.200.620.98
C6-DC-carnitine0.290.01*0.77
C8-carnitine0.410.100.20
C8-DC-carnitine0.840.00*0.55
C10-carnitine0.200.110.20
C5 :  1-DC/C10 : 1-OH-carnitine0.820.100.90
C12-carnitine0.200.110.15
C14-carnitine0.410.200.70
C16-carnitine0.210.070.95
*Differences are considered to be statistically significant compared to baseline values if 𝑃 < . 0 5 .