Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism

Table 2

Paired 𝑡-test values (𝑃-values) of amino acids in baseline urine samples compared to amino acids in urine samples obtained after acetylsalicylic acid administration (𝑛=7), acetaminophen administration (𝑛=7), and combined administration of both acetylsalicylic acid and acetaminophen (𝑛=30).

Amino Acids	Paired 𝑡-test (𝑃-value)
	Acetylsalicylic acid administration (𝑛=7)	Acetaminophen administration (𝑛=7)	Combined administration (𝑛=30)
Alanine	0.00*	0.00*	0.50
Glycine	0.03*	0.02*	0.82
Valine	0.02*	0.01*	0.01*
Leucine	0.04*	0.03*	0.04*
Isoleucine	0.02*	0.01*	0.00*
Methionine	0.01*	0.01*	0.73
Proline/Arginine	0.06	0.02*	0.21
Phenylalanine	0.02*	0.01*	0.43
Tryptophan	0.12	0.03*	0.01*
Serine	0.06	0.03*	0.32
Threonine	0.19	0.07	0.31
Tyrosine	0.01*	0.00*	0.13
Lysine	0.03*	0.03*	0.45
Histidine	0.01*	0.00*	0.20
Aspartic acid	0.05*	0.05*	1.00
Glutamic acid	0.02*	0.02*	0.39

*Differences are considered to be statistically significant compared to baseline values if 𝑃<.05.