Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 852619, 6 pages
http://dx.doi.org/10.5402/2011/852619
Research Article

Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge

1Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903-0213, Japan
2Department of Marine Sciences, Faculty of Fisheries and Marine Sciences, University of Diponegoro, Semarang, Central Java 50234, Indonesia

Received 2 May 2011; Accepted 27 May 2011

Academic Editors: T. Schotten and X.-W. Yang

Copyright © 2011 Agus Trianto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Purification of the extract yielded two new macrolides 2 and 3 along with known candidaspongiolide (1). The structures for compounds 2 and 3 were elucidated by spectral analysis ( 1 H , 1 3 C , COSY, HMQC, HMBC) and by comparison of their NMR data with those of 1. Compounds 2 and 3 exhibited a little more potent cytotoxicity ( I C 5 0 4.7 and 19 ng/mL) than that ( I C 5 0 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.