Evaluation of the Biocompatibility of a Bilayer Chitosan Skin Regenerating Template, Human Skin Allograft, and Integra Implants in Rats

Table 1

Mean score and standard deviation (in brackets) of inflammatory cells, angiogenesis, granuloma, giant cells and tissue invagination upon histological examination.

Day	4	7	14	21	28
Inflammation
Chitosan SRT	2.1 (0.3)	2.9 (0.3)	2.0 (0.5)	2.0 (0.5)	2.1 (0.3)
Integra	2.0 (0.4)	3.0 (0.5)	4.9 (0.3)	2.1 (0.3)	1.2 (0.4)
HSA	2.9 (0.3)	4.8 (0.4)	4.8 (0.4)	2.1 (0.3)	1.1 (0.3)
P value	<0.001	<0.001	<0.001	0.799	<0.001
Angiogenesis
Chitosan SRT	4.9 (0.3)	4.0 (0.5)	2.2 (0.4)	2.1 (0.3)	2.1 (0.3)
Integra	4.9 (0.3)	2.1 (0.3)	2.2 (0.4)	2.1 (0.3)	2.1 (0.3)
HAS	4.9 (0.3)	4.8 (0.4)	4.8 (0.4)	4.8 (0.4)	2.1 (0.3)
P value	>0.995	<0.001	<0.001	<0.001	>0.995
Granuloma
Chitosan SRT	0.1 (0.3)	1.1 (0.3)	1.1 (0.3)	1.1 (0.3)	1.9 (0.3)
Integra	0.1 (0.3)	0.9 (0.3)	0.9 (0.3)	1.9 (0.3)	1.1 (0.3)
HSA	1.0 (0.00)	0.9 (0.3)	1.1 (0.3)	0.9 (0.3)	0.1 (0.3)
P value	<0.001	0.275	0.275	<0.001	<0.001
Giant cells
Chitosan SRT	0.9 (0.3)	0.9 (0.3)	1.1 (0.3)	1.9 (0.3)	1.1 (0.3)
Integra	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)
HAS	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)	0.1 (0.3)
P value	<0.001	<0.001	<0.001	<0.001	<0.001
Tissue invagination
Chitosan SRT	4.9 (0.3)	4.9 (0.3)	4.8 (0.4)	4.9 (0.3)	4.9 (0.3)
Integra	4.9 (0.3)	4.8 (0.4)	4.9 (0.3)	4.8 (0.4)	4.8 (0.4)
HSA	0.1 (0.3)	1.1 (0.3)	2.9 (0.3)	2.8 (2.0)	4.9 (0.3)
P value	<0.001	<0.001	<0.001	0.757	<0.001