Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011 (2011), Article ID 858647, 8 pages
http://dx.doi.org/10.5402/2011/858647
Research Article

Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers

1Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
2Department of Gynecologic Oncology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
3Molecular Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA

Received 22 September 2010; Accepted 19 October 2010

Academic Editors: W.-F. Cheng, E. Petru, M. T. Sanseverino, and A. Zenclussen

Copyright © 2011 Mamatha Chivukula et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. W. Kindelberger, Y. Lee, A. Miron et al., “Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship,” American Journal of Surgical Pathology, vol. 31, no. 2, pp. 161–169, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. WHO fascicle, Tumors of the Breast and Female Genital Organs, IRAC Press, 2003.
  3. A. K. Folkins, E. A. Jarboe, M. H. Roh, and C. P. Crum, “Precursors to pelvic serous carcinoma and their clinical implications,” Gynecologic Oncology, vol. 113, no. 3, pp. 391–396, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Hashi, T. Yuminamochi, S. I. Murata, H. Iwamoto, T. Honda, and K. Hoshi, “Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian tube, ovary, endometrium, and peritoneum,” International Journal of Gynecological Pathology, vol. 22, no. 4, pp. 374–377, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Hwang, L. Quenneville, H. Yaziji, and A. M. Gown, “Wilms tumor gene product: sensitive and contextually specific marker of serous carcinomas of ovarian surface epithelial origin,” Applied Immunohistochemistry and Molecular Morphology, vol. 12, no. 2, pp. 122–126, 2004. View at Google Scholar · View at Scopus
  6. C. P. Crum, R. Drapkin, D. Kindelberger, F. Medeiros, A. Miron, and Y. Lee, “Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer,” Clinical Medicine and Research, vol. 5, no. 1, pp. 35–44, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. W. Carlson, A. Miron, E. A. Jarboe et al., “Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention,” Journal of Clinical Oncology, vol. 26, no. 25, pp. 4160–4165, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. K. Folkins, E. A. Jarboe, A. Saleemuddin et al., “A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations,” Gynecologic Oncology, vol. 109, no. 2, pp. 168–173, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Dahl, H. Koseki, and R. Balling, “Pax genes and organogenesis,” BioEssays, vol. 19, no. 9, pp. 755–765, 1997. View at Google Scholar · View at Scopus
  10. L. Daniel, E. Lechevallier, R. Giorgi et al., “Pax-2 expression in adult renal tumors,” Human Pathology, vol. 32, no. 3, pp. 282–287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Saleemuddin, A. K. Folkins, L. Garrett et al., “Risk factors for a serous cancer precursor ("p53 signature") in women with inherited BRCA mutations,” Gynecologic Oncology, vol. 111, no. 2, pp. 226–232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. G. X. Tong, J. Melamed, M. Mansukhani et al., “PAX2: a reliable marker for nephrogenic adenoma,” Modern Pathology, vol. 19, no. 3, pp. 356–363, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Chivukula, D. J. Dabbs, S. O'Connor, and R. Bhargava, “PAX 2: a novel müllerian marker for serous papillary carcinomas to differentiate from micropapillary breast carcinoma,” International Journal of Gynecological Pathology, vol. 28, no. 6, pp. 570–578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. G. X. Tong, L. Chiriboga, D. Hamele-Bena, and A. C. Borczuk, “Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?” Modern Pathology, vol. 20, no. 8, pp. 856–863, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Al-Hussaini, A. Stockman, H. Foster, and W. G. McCluggage, “WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma,” Histopathology, vol. 44, no. 2, pp. 109–115, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Chivukula and M. Kapali, “Expression of Wilms tumor gene (WT-1) in primary peritoneal papillary serous carcinomas,” in Proceedings of the 94th Annual Meeting of United States and Canadian Academy of Pathology, San Antonio, Tex, USA, 2005, Abstract no. 150. Poster.
  17. J. A. Egan, M. C. Ionescu, E. Eapen, J. G. Jones, and D. S. Marshall, “Differential expression of WT1 and p53 in serous and endometrioid carcinomas of the endometrium,” International Journal of Gynecological Pathology, vol. 23, no. 2, pp. 119–122, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Jarboe, A. Folkins, M. R. Nucci et al., “Serous carcinogenesis in the fallopian tube: a descriptive classification,” International Journal of Gynecological Pathology, vol. 27, no. 1, pp. 1–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Y. Chen, K. Mehra, M. Mehrad et al., “Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube,” Journal of Pathology, vol. 222, no. 1, pp. 110–116, 2010. View at Publisher · View at Google Scholar