Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers

Table 3

Immunohistochemical (IHC) and loss of heterozygosity (LOH) analysis of Group 1: primary fallopian tube carcinoma (PFTC) and associated tubal intraepithelial carcinoma (TIC).

PPSC/+	Associated TIC						PFTC
	PAX 2		WT-1		P53		PAX 2		WT-1		P53
	* IHC (CS)	LOH	* IHC (CS)	LOH	* IHC (CS)	LOH	* IHC (CS)	LOH	* IHC (CS)	LOH	* IHC (CS)	LOH
^♦Case 1	0	No LOH	7	No LOH	7	LOH	0	No LOH	6	No LOH	7	LOH
Case 2	0		3		7	No LOH	3	LOH	7	No LOH	7	No LOH
Case 3	6		7		0		6	No LOH	7	LOH	7	No LOH
Case 4	0		7		7		6	No LOH	7	LOH	7	LOH
^♦Case 5	2	LOH	7	No LOH	0		3	No LOH	7	No LOH	0	No LOH
^♦Case 6	7	LOH	6	LOH	7	No LOH	7	LOH	7	No LOH	7	No LOH
Case 7	0		7		7		0	No LOH	7	No LOH	7	No LOH
Case 8	3		7		7		**0	LOH	7	No LOH	7	LOH
^♦Case 9	**0	LOH	7	LOH	**0	LOH	0	No LOH	7	LOH	0	No LOH
Case 10	6		7		7		6	No LOH	7	No LOH	7	No LOH

* IHC (CS): a cumulative score (CS) was calculated incorporating PS as well as IS. The score was derived by the summation of PS and IS, ranged from 0 to 8 and is further divided into Negative (0), Weak (1-2), Moderate (3–5), Strong (6–8).
(**): PAX signature; (^♦): 4 cases of TIC on which LOH was performed.