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Research Article

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Table 6

Effect of MECL on different tissue enzymes of normal and hyperglycaemic rats.
Group DoseLipid peroxidation (mM 100 g−1 of tissue )Glutathione (mg 100 g−1 of tissue)
PancreasLiverKidneyPancreasLiverKidney
Saline control5 mL/kg (p.o.) 1 . 1 4 ± 0 . 0 8 1 . 0 2 ± 0 . 0 5 1 . 4 9 ± 0 . 1 3 4 . 5 6 ± 3 . 2 4 9 . 3 ± 2 . 1 2 3 . 6 ± 1 . 3
STZ control65 mg/kg (i.p.) 1 . 8 ± 0 . 0 9 * 1 . 8 5 ± 0 . 0 9 * 2 . 3 4 ± 0 . 6 * 1 3 . 7 ± 1 . 4 * 2 5 . 9 ± 1 . 5 * 6 . 4 ± 2 . 4 *
STZ + MECL200 mg/kg (p.o.) 1 . 4 ± 0 . 0 2 ** 1 . 4 ± 0 . 0 8 ** 1 . 7 ± 0 . 0 8 ** 4 1 . 0 9 ± 0 . 0 2 4 ** 2 7 . 4 ± 0 . 6 2 ** 1 8 . 8 6 ± 0 . 1 6 **
STZ + MECL400 mg/kg (p.o.) 1 . 3 1 ± 0 . 0 9 ** 1 . 1 2 ± 0 . 0 7 ** 1 . 6 2 ± 0 . 0 2 ** 3 6 . 0 8 ± 0 . 0 5 ** 3 1 . 7 5 ± 0 . 0 3 1** 1 7 . 1 4 ± 0 . 2 9 **
STZ + Glibenclamide0.5 mg/kg (p.o.) 1 . 2 3 ± 0 . 0 7 ** 1 . 0 7 ± 0 . 0 2 ** 1 . 5 1 ± 0 . 0 6 ** 4 1 . 3 1 ± 2 . 3 ** 4 1 . 7 8 ± 2 . 1 ** 1 9 . 6 1 ± 1 . 5 **
Values are expressed as mean ± SEM ( 𝑛 = 6 ); * 𝑃 < 0 . 0 0 1 compared with saline control group and ** 𝑃 < 0 . 0 0 1 compared with STZ-control group.