Table of Contents
ISRN Cardiology
Volume 2011 (2011), Article ID 897908, 5 pages
http://dx.doi.org/10.5402/2011/897908
Research Article

Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIV/AIDS

1Faculty of Health Sciences, Walter Sisulu University, Mthatha 5117, South Africa
2Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo
3Department of Radiology, Kinshasa University, Democratic Republic of Congo
4University of Marien Ngouabi, Brazzaville, Democratic Republic of Congo
5Lomo Medical Cardiovascular Centre for Africa, Limete, Kinshasa, Democratic Republic of Congo

Received 28 January 2011; Accepted 22 March 2011

Academic Editor: J. Wang

Copyright © 2011 Benjamin Longo-Mbenza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Purpose. It now appears clear that both HIV/AIDS and antiretroviral therapy (HAART) use are associated with higher risk of cardiovascular disease such as stroke. In this study, we evaluated the prevalence, the risk factors, and the cardiometabolic comorbidities of stroke in HIV/AIDS Central African patients. Methods. This hospital-based cross-sectional study collected clinical, laboratory, and imaging data of black Central African heterosexual, intravenous drug nonuser, and HIV/AIDS patients. Results. There were 54 men and 62 women, with a female to male ratio of 1.2 : 1. All were defined by hypercoagulability and oxidative stress. Hemorrhagic stroke was reported in 1 patient, ischemic stroke in 17 patients, and all stroke subtypes in 18 patients (15%). Younger age <45 years ( 𝑃 = . 0 0 3 ) , autoimmunity ( 𝑃 < . 0 0 0 1 ) , and metabolic syndrome defined by IDF criteria ( 𝑃 < . 0 0 0 1 ) were associated with ischemic stroke. Conclusions. Clustering of several cardiometabolic factors, autoimmunity, oxidative stress, and lifestyle changes may explain accelerated atherosclerosis and high risk of stroke in these young black Africans with HIV/AIDS. Prevention and intervention programs are needed.