The Role of p53 and MDM2 in Head and Neck Cancer

Table 1

Some of the most impressive studies on p53-MDM2 correlations.

Author	Pts	Biological predictors/prognosticators	Correlations	p
Michalides et al. [28]	198	MDM2, MTBP, p53, and HNSCC OS*	Low MDM2 versus high MDM2	0.248
			P53+ AND low MDM2 versus other status	0.035
Poeta et al. [29]	53	P53 and RR after P-based NACT	4/15 CR versus 20/38 NR	0.12
Nakashima et al. [24]	76	P53, MDM2, Rb, and dysplasia	HNSCC	P53 66% MDM2 46%
			Hyperplastic lesions	P53 55% MDM2 31%
			Dysplastic lesion	P53 64% MDM2 44%
Hamid et al. [27]	62	MDM2, p53, HNSCC OS, and stage	P53+ AND low MDM2	0.07
			P53+ AND IHC staining	0.018
			MDM2 and T stage	0.10
			MDM2 and T4 versus T1	0.015
			Low MDM2 and 3 y OS	0.034
Chen et al. [34]	660**	MDM2 polymorphism and HPV 16 seropositivity	MDM2-rs2279744 TT versus GT	OR=0.64
			MDM2-rs2279744 TT versus GG	OR=0.60
			MDM2-rs2279744 TT versus GT/GG	OR=0.62
			MDM2-rs2279744 TT versus AG	OR=2.20
			MDM2-rs2279744 TT versus AG/GG	OR=2.05
Gasco and Crook [17]	2073***	MDM2, p53, and HNSCC onset	MDM2 SNP309	0.638
			MDM2 A2164G	0.580
			P53 codon 72	0.193
Agarwal et al. [38]	128****	MDM2, p53, and prognosis	MDM2 mut/p53+ AND stage III/IV	0.0009
			MDM2 mut/p53+ AND N+	0.0325
Sullivan et al. [20]	73	p53 and OS	P53 72R versus p53 72P	0.007
			wt p53 (72R or 72P) versus no wt P53	0.0001
			P53 72R versus p53 72P + 72R	0.02
Bergamaschi et al. [5]	70	p53, p73, OS, and response	CR: p53 wt versus no wt P53	0.0001
			PFS: p53 wt versus no wt P53	0.0007
			PFS: p53 72R versus 72P	0.008
			OS: p53 72R versus 72P	0.0044
			PFS: p73−/p53+ versus p73+/p53+	0.05
Hamid et al. [27]	420	p53 and OS	p53+ versus p53−	0.074
			p53+ disruptive versus p53+ nondisruptive	0.001
				RR=1.17

*= OS after surgery; **= 335 controls; ***= 1090 control population; ****= 33 premalignant lesion and 30 control normal oral tissues.
OS = overall survival; NACT = neoadjuvant chemotherapy; OR = odd ratio; RR = response rate; CR = complete response.
IHC = immuhistochemical; NR = nonresponse;
3y = 3 year; p53+ = p53 mutated; p53 codon 72 = mutation in codon 72.
72R = arginine at codon 72 of p53.
72P = proline at codon 72 of p53.
p73−/p53+ = non-p73-inactivating p53 mutations. p73+/p53+ = p73-inactivative and p53 mutations.