Research Article

The Characterization of the Repertoire of Wheat Antigens and Peptides Involved in the Humoral Immune Responses in Patients with Gluten Sensitivity and Crohn's Disease

Table 3

IgA antibody expressed as optical density (OD) against wheat and all gliadin, glutenin peptides, exorphins, gliadin-transglutaminase, transglutaminase, and WGA in healthy control subjects and patients with celiac and Crohn’s disease.

Wheat (OD) 𝛼 -Gliadin 33 (OD) 𝛼 -Gliadin 17 (OD) 𝛾 -Gliadin 15 (OD) 𝜔 -Gliadin 17 (OD)Glutenin 21 (OD)Gluteo-morphin (OD)Pro-dynorphin (OD)Gliadin + transglut (OD)Transglut (OD)WGA (OD)

Control mean ± SD 0 . 2 3 ± 0 . 1 5 0 . 1 1 ± 0 . 0 9 0 . 2 5 ± 0 . 2 6 0 . 1 1 ± 0 . 0 6 0 . 1 3 ± 0 . 0 8 0 . 2 3 ± 0 . 2 3 0 . 1 9 ± 0 . 1 6 0 . 1 3 ± 0 . 1 0 0 . 0 6 ± 0 . 0 6 0 . 1 0 ± 0 . 0 7 0 . 1 1 ± 0 . 0 7

Gluten sensitive Patient mean ± SD 0 . 8 9 ± 0 . 3 0 0 . 2 8 ± 0 . 3 7 0 . 4 5 ± 0 . 5 1 0 . 7 1 ± 0 . 6 0 0 . 5 2 ± 0 . 5 4 0 . 6 6 ± 0 . 5 1 0 . 4 5 ± 0 . 4 8 0 . 8 4 ± 0 . 5 6 0 . 6 1 ± 0 . 5 1 1 . 0 1 ± 0 . 6 0 1 . 1 1 ± 0 . 9 5

𝑃 values0.00010.01950.04110.00010.00090.00030.00780.00010.00010.00010.0001

Crohn’s patient Mean ± SD 0 . 2 9 ± 0 . 5 0 0 . 1 3 ± 0 . 3 5 0 . 1 5 ± 0 . 3 3 0 . 3 9 ± 0 . 4 9 0 . 1 1 ± 0 . 2 9 0 . 1 5 ± 0 . 2 8 0 . 1 4 ± 0 . 2 8 0 . 4 4 ± 0 . 5 0 0 . 1 2 ± 0 . 2 5 0 . 5 2 ± 0 . 7 3 0 . 4 0 ± 0 . 8 1

𝑃 values0.27770.38590.09350.00440.33120.09920.21060.00350.15440.00470.0517