Table of Contents
ISRN Gastroenterology
Volume 2011, Article ID 972838, 5 pages
Research Article

Intestinal Fluid and Glucose Transport in Wistar Rats following Chronic Consumption of Fresh or Oxidised Palm Oil Diet

Department of Physiology, College of Medical Sciences, University of Calabar, 540001 Calabar, Nigeria

Received 6 September 2010; Accepted 12 October 2010

Academic Editors: G. D. Mazzolini and A. A. te Velde

Copyright Β© 2011 Agona O. Obembe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic ingestion of thermoxidized palm oil causes functional derangement of various tissues. This study was therefore carried out to determine the effect of chronic ingestion of thermoxidized and fresh palm oil diets on intestinal fluid and glucose absorption in rats using the everted sac technique. Thirty Wistar rats were divided into three groups of 10 rats per group. The first group was the control and was fed on normal rat chow while the second (FPO) and third groups (TPO) were fed diet containing either fresh or thermoxidized palm oil (15% wt/wt) for 14 weeks. Villus height and crypt depth were measured. The gut fluid uptake and gut glucose uptake were significantly ( 𝑃 < . 0 0 1 ) lower in the TPO group than those in the FPO and control groups, respectively. The villus height in the TPO was significantly ( 𝑃 < . 0 1 ) lower than that in FPO and control. The villus depth in TPO was significantly ( 𝑃 < . 0 5 ) higher than that in FPO and control groups, respectively. These results suggest that ingestion of thermoxidized palm oil and not fresh palm oil may lead to distortion in villus morphology with a concomitant malabsorption of fluid and glucose in rats due to its harmful free radicals.