Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 980105, 7 pages
http://dx.doi.org/10.5402/2011/980105
Research Article

Altered or Impaired Immune Response to Hepatitis B Vaccine in WNIN/GR-Ob Rat: An Obese Rat Model with Impaired Glucose Tolerance

1Department of Microbiology, National Institute of Nutrition, Jamai Osmania, Hyderabad 500 604, India
2National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania, Andhra Pradesh, Hyderabad 500 604, India

Received 14 May 2011; Accepted 19 June 2011

Academic Editors: C. Anderwald and W. B. Chan

Copyright © 2011 Prathibha Bandaru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. M. Flegal, B. I. Graubard, D. F. Williamson, and M. H. Gail, “Cause-specific excess deaths associated with underweight, overweight, and obesity,” Journal of the American Medical Association, vol. 298, no. 17, pp. 2028–2037, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. E. Falagas and M. Kompoti, “Obesity and infection,” Lancet Infectious Diseases, vol. 6, no. 7, pp. 438–446, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. B. J. Plotkin, D. Paulson, A. Chelich et al., “Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): susceptibility to Candida albicans infection and leucocyte function,” Journal of Medical Microbiology, vol. 44, no. 4, pp. 277–283, 1996. View at Google Scholar · View at Scopus
  4. S. Ikejima, S. Sasaki, H. Sashinami et al., “Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice,” Diabetes, vol. 54, no. 1, pp. 182–189, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Amar, Q. Zhou, Y. Shaik-Dasthagirisaheb, and S. Leeman, “Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 51, pp. 20466–20471, 2007. View at Publisher · View at Google Scholar
  6. A. G. Smith, P. A. Sheridan, J. B. Harp, and M. A. Beck, “Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus,” Journal of Nutrition, vol. 137, no. 5, pp. 1236–1243, 2007. View at Google Scholar · View at Scopus
  7. J. Palmblad, D. Hallberg, and L. Engstedt, “Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesity,” British Journal of Haematology, vol. 44, no. 1, pp. 101–108, 1980. View at Google Scholar · View at Scopus
  8. S. Tanaka, F. Isoda, Y. Ishihara, M. Kimura, and T. Yamakawa, “T lymphopaenia in relation to body mass index and TNF-alpha in human obesity: adequate weight reduction can be corrective,” Clinical Endocrinology, vol. 54, no. 3, pp. 347–354, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Martí, A. Marcos, and J. A. Martínez, “Obesity and immune function relationships,” Obesity Reviews, vol. 2, no. 2, pp. 131–140, 2001. View at Google Scholar · View at Scopus
  10. O. Lamas, J. A. Martinez, and A. Marti, “T-helper lymphopenia and decreased mitogenic response in cafeteria diet-induced obese rats,” Nutrition Research, vol. 22, no. 4, pp. 497–506, 2002. View at Publisher · View at Google Scholar
  11. D. J. Weber, W. A. Rutala, and G. P. Samsa, “Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine,” The Journal of the American Medical Association, vol. 254, no. 22, pp. 3187–3189, 1985. View at Google Scholar
  12. J. Simo Minana, M. Gaztambide Ganuza, P. Fernandez Millan, and M. Pena Fernandez, “Hepatitis B vaccine immunoresponsiveness in adolescents: a revaccination proposal after primary vaccination,” Vaccine, vol. 14, no. 2, pp. 103–106, 1996. View at Publisher · View at Google Scholar
  13. A. Eliakim, C. Schwindt, F. Zaldivar, P. Casali, and D. M. Cooper, “Reduced tetanus antibody titers in overweight children,” Autoimmunity, vol. 39, no. 2, pp. 137–141, 2006. View at Google Scholar
  14. P. Bandaru, H. Rajkumar, and G. Nappanveettil, “Altered or impaired immune response upon vaccination in WNIN/Ob rats,” Vaccine, vol. 29, no. 16, pp. 3038–3042, 2011. View at Publisher · View at Google Scholar
  15. N. V. Giridharan, N. Harishankar, and M. Satyavani, “A new rat model for the study of obesity,” Scandinavian Journal of Laboratory Animal Science, vol. 23, no. 3, pp. 131–137, 1996. View at Google Scholar
  16. S. M. Jeyakumar, P. Lopamudra, S. Padmini, N. Balakrishna, N. V. Giridharan, and A. Vajreswari, “Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob,” Nutrition and Metabolism, vol. 6, article no. 27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Sheril, S. M. Jeyakumar, T. Jayashree, N. V. Giridharan, and A. Vajreswari, “Impact of feeding polyunsaturated fatty acids on cholesterol metabolism of dyslipidemic obese rats of WNIN/GR-Ob strain,” Atherosclerosis, vol. 204, no. 1, pp. 136–140, 2009. View at Publisher · View at Google Scholar
  18. K. S. Jayaraman, “'Sumo' rats set researchers on hunt for obesity genes,” Nature Medicine, vol. 11, no. 2, p. 108, 2005. View at Google Scholar
  19. N. Harishankar, A. Vajreswari, and N. V. Giridharan, “WNIN/GR-Ob—an insulin-resistant obese rat model from inbred WNIN strain for studies on obesity associated with diabetes,” Indian Journal of Medical Research. In press.
  20. S. Moriguchi, M. Kalo, K. Sakai, S. Yamamoto, and E. Shimizu, “Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter 1 (GLUT- 1),” American Journal of Clinical Nutrition, vol. 67, no. 6, pp. 1124–1129, 1998. View at Google Scholar
  21. M. A. Pahlavani, D. A. Vargas, T. R. Evans, J. H. Shu, and J. F. Nelson, “Melatonin fails to modulate immune parameters influenced by calorie restriction in aging Fischer 344 rats,” Experimental Biology and Medicine, vol. 227, no. 3, pp. 201–207, 2002. View at Google Scholar · View at Scopus
  22. F. Ozgenc, G. Aksu, F. Kirkpinar et al., “The influence of marginal zinc deficient diet on post-vaccination immune response against hepatitis B in rats,” Hepatology Research, vol. 35, no. 1, pp. 26–30, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Sleijffers, J. Garssen, F. R. de Gruijl et al., “UVB exposure impairs immune responses after hepatitis B vaccination in two different mouse strains,” Photochemistry and Photobiology, vol. 75, no. 5, pp. 541–546, 2002. View at Google Scholar · View at Scopus
  24. M. C. Blanc, C. Moinard, A. Béziel, S. Darquy, L. Cynober, and J. P. De Bandt, “Arginine and glutamine availability and macrophage functions in the obese insulin-resistant Zucker rat,” Journal of Cellular Physiology, vol. 202, no. 1, pp. 153–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. K. D. Kroncke, K. Fehsel, and V. Kolb-Bachofen, “Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities,” Biological Chemistry Hoppe-Seyler, vol. 376, no. 6, pp. 327–343, 1995. View at Google Scholar · View at Scopus
  26. N. Mito, T. Hosoda, C. Kato, and K. Sato, “Change of cytokine balance in diet-induced obese mice,” Metabolism, vol. 49, no. 10, pp. 1295–1300, 2000. View at Publisher · View at Google Scholar
  27. T. E. Saaristo, N. C. Barengo, E. Korpi-Hyövälti et al., “High prevalence of obesity, central obesity and abnormal glucose tolerance in the middle-aged Finnish population,” BMC Public Health, vol. 8, article 423, 2008. View at Publisher · View at Google Scholar
  28. K. Supreet and K. Umesh, “Impaired glucose tolerance and diabetes mellitus in obese children,” Indian Pediatrics, vol. 47, no. 4, pp. 362–363, 2010. View at Google Scholar
  29. E. L. Barr, P. Z. Zimmet, T. A. Welborn et al., “Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: The Australian Diabetes, Obesity, and Lifestyle Study (AusDiab),” Circulation, vol. 116, no. 2, pp. 151–157, 2007. View at Publisher · View at Google Scholar
  30. M. R. Ruth, C. G. Taylor, P. Zahradka, and C. J. Field, “Abnormal immune responses in fa/fa Zucker rats and effects of feeding conjugated linoleic acid,” Obesity, vol. 16, no. 8, pp. 1770–1779, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Tanaka, F. Isoda, T. Yamakawa, M. Ishihara, and H. Sekihara, “T lymphopenia in genetically obese rats,” Clinical Immunology and Immunopathology, vol. 86, no. 2, pp. 219–225, 1998. View at Publisher · View at Google Scholar
  32. C. Verwaerde, A. Delanoye, L. Macia, A. Tailleux, and I. Wolowczuk, “Influence of high-fat feeding on both naive and antigen-experienced T-cell immune response in DO10.11 mice,” Scandinavian Journal of Immunology, vol. 64, no. 5, pp. 457–466, 2006. View at Publisher · View at Google Scholar
  33. R. K. Chandra, “Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice,” American Journal of Clinical Nutrition, vol. 33, no. 1, pp. 13–16, 1980. View at Google Scholar
  34. G. Fernandes, B. S. Handwerger, E. J. Yunis, and D. M. Brown, “Immune response in the mutant diabetic C57BL/Ks-db+ mouse,” Journal of Clinical Investigation, vol. 61, no. 2, pp. 243–250, 1978. View at Google Scholar
  35. F. B. Hollinger, “Factors influencing the immune response to hepatitis B vaccine, booster dose guidelines, and vaccine protocol recommendations,” The American Journal of Medicine, vol. 87, no. 3, pp. 36S–40S, 1989. View at Google Scholar · View at Scopus
  36. C. Bogdan, M. Röllinghoff, and A. Diefenbach, “The role of nitric oxide in innate immunity,” Immunological Reviews, vol. 173, pp. 17–26, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. S. N. Zykova, T. G. Jenssen, M. Berdal, R. Olsen, R. Myklebust, and R. Seljelid, “Altered cytokine and nitric oxide secretion in vitro by macrophages from diabetic type II-like db/db mice,” Diabetes, vol. 49, no. 9, pp. 1451–1458, 2000. View at Google Scholar · View at Scopus
  38. M. John, X. Qiao-wen, and N. Carl, “Nitric oxide and macrophage function,” Annual Review of Immunology, vol. 15, pp. 323–350, 1997. View at Publisher · View at Google Scholar
  39. M. Zembala, D. Kowalczyk, J. Pryjma et al., “The role of tumor necrosis factor in the regulation of antigen presentation by human monocytes,” International Immunology, vol. 2, no. 4, pp. 337–342, 1990. View at Google Scholar · View at Scopus
  40. S. Yokota, T. D. Geppert, and P. E. Lipsky, “Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha,” Journal of Immunology, vol. 140, no. 2, pp. 531–536, 1988. View at Google Scholar · View at Scopus
  41. S. Bedoui, E. Velkoska, S. Bozinovski, J. E. Jones, G. P. Anderson, and M. J. Morris, “Unaltered TNF-α production by macrophages and monocytes in diet-induced obesity in the rat,” Journal of Inflammation, vol. 2, p. 2, 2005. View at Publisher · View at Google Scholar
  42. K. N. Traill and G. Wick, “Lipids and lymphocyte function,” Immunology Today, vol. 5, no. 3, pp. 70–76, 1984. View at Google Scholar
  43. M. I. Gurr, “The role of lipids in the regulation of the immune system,” Progress in Lipid Research, vol. 22, no. 4, pp. 257–287, 1983. View at Google Scholar · View at Scopus
  44. M. G. Pallavicini and W. K. Nichols, “Inhibition of lymphocyte blastogenesis by factor(s) in a alloxan diabetic rat plasma,” Diabetes, vol. 25, pp. 14–22, 1976. View at Google Scholar · View at Scopus
  45. A. M. Attallah, H. Abdelghaffar, A. Fawzy et al., “Cell-mediated immunity and biological response modifiers in insulin-dependent diabetes mellitus complicated by end-stage renal disease,” International Archives of Allergy and Applied Immunology, vol. 83, no. 3, pp. 278–283, 1987. View at Google Scholar
  46. L. Ozsari, N. Karadurmus, M. Sahin, G. Uckaya, A. U. Ural, and M. Kutlu, “Comparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patients,” Endocrine, vol. 37, no. 1, pp. 135–139, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. A. A. Howard, Y. Lo, and M. Floris-Moore, “Hepatitis C virus infection is associated with insulin resistance among older adults with or at risk of HIV infection,” AIDS, vol. 21, no. 5, pp. 633–641, 2007. View at Publisher · View at Google Scholar · View at Scopus