Altered or Impaired Immune Response to Hepatitis B Vaccine in WNIN/GR-Ob Rat: An Obese Rat Model with Impaired Glucose Tolerance
Mitogen stimulated IL2 cytokine production by splenocytes and LPS-stimulated TNF-α and NO production by peritoneal macrophages to Hepatitis B vaccine in 3-month-old WNIN/GR-Ob lean and obese rats.
WNIN/GR-Ob lean unvaccinated ()
WNIN/GR-Ob obese unvaccinated ()
WNIN/GR-Ob lean vaccinated ()
WNIN/GR-Ob obese vaccinated ()
Con A stimulated IL2 production (ng/mL)
1505 ± 446
1087 ± 149
1423 ± 323
940 ± 290
LPS stimulated TNF-α release (ng/mL)
1642 ± 748a,b
430 ± 17a,b
1974 ± 449*a
384 ± 28b
LPS stimulated NO production (ng/mL)
1.96 ± 0.35*a
4.4 ± 0.35b
4.7 ± 0.66b
4.25 ± 1.34a,b
Values are in mean ± SE; * (significant difference between unvaccinated and vaccinated groups of lean and obese rats). The means bearing similar superscripts in each row do not differ significantly.
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