International Scholarly Research Notices / 2011 / Article / Tab 2

Research Article

Altered or Impaired Immune Response to Hepatitis B Vaccine in WNIN/GR-Ob Rat: An Obese Rat Model with Impaired Glucose Tolerance

Table 2

Mitogen stimulated IL2 cytokine production by splenocytes and LPS-stimulated TNF-α and NO production by peritoneal macrophages to Hepatitis B vaccine in 3-month-old WNIN/GR-Ob lean and obese rats.

Immune parametersWNIN/GR-Ob lean unvaccinated ( 𝑛 = 6 )WNIN/GR-Ob obese unvaccinated ( 𝑛 = 6 )WNIN/GR-Ob lean vaccinated ( 𝑛 = 8 )WNIN/GR-Ob obese vaccinated ( 𝑛 = 8 )

Con A stimulated IL2 production (ng/mL)1505 ± 4461087 ± 1491423 ± 323940 ± 290
LPS stimulated TNF-α release (ng/mL)1642 ± 748a,b430 ± 17a,b1974 ± 449*a384 ± 28b
LPS stimulated NO production (ng/mL)1.96 ± 0.35*a4.4 ± 0.35b4.7 ± 0.66b4.25 ± 1.34a,b

Values are in mean ± SE; * 𝑃 < 0 . 0 5 (significant difference between unvaccinated and vaccinated groups of lean and obese rats). The means bearing similar superscripts in each row do not differ significantly.

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