Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 103472, 8 pages
http://dx.doi.org/10.5402/2012/103472
Review Article

The Malnutrition of Obesity: Micronutrient Deficiencies That Promote Diabetes

Division of Endocrinology and Metabolism, Beth Israel Medical Center, Albert Einstein College of Medicine, 55 East 34th St, USA

Received 13 December 2011; Accepted 5 January 2012

Academic Editors: C. Anderwald and A. Hishinuma

Copyright © 2012 Michael Via. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. T. Hurt, T. H. Frazier, S. A. McClave, and L. M. Kaplan, “Obesity epidemic: overview, pathophysiology, and the intensive care unit conundrum,” Journal of Parenteral and Enteral Nutrition, vol. 35, no. 5, pp. 4S–13S, 2011. View at Google Scholar
  2. K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999–2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. B. A. Swinburn, G. Sacks, K. D. Hall et al., “The global obesity pandemic: shaped by global drivers and local environments,” The Lancet, vol. 378, no. 9793, pp. 804–814, 2011. View at Publisher · View at Google Scholar
  4. M. N. Riaz, M. Asif, and R. Ali, “Stability of vitamins during extrusion,” Critical Reviews in Food Science and Nutrition, vol. 49, no. 4, pp. 361–368, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. O. Kaidar-Person, B. Person, S. Szomstein, and R. J. Rosenthal, “Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part A: vitamins,” Obesity Surgery, vol. 18, no. 7, pp. 870–876, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. O. Kaidar-Person, B. Person, S. Szomstein, and R. J. Rosenthal, “Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B: minerals,” Obesity Surgery, vol. 18, no. 8, pp. 1028–1034, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. K. Niswender, “Diabetes and obesity: therapeutic targeting and risk reduction—a complex interplay,” Diabetes, Obesity and Metabolism, vol. 12, no. 4, pp. 267–287, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. R. A. Defronzo, “From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus,” Diabetes, vol. 58, no. 4, pp. 773–795, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. E. Strohmayer, M. A. Via, and R. Yanagisawa, “Metabolic management following bariatric surgery,” Mount Sinai Journal of Medicine, vol. 77, no. 5, pp. 431–445, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. Institute of Medicine, Dietary Reference Intakes of Calcium and Vitamin D, National Academic Press, Washington, DC, USA, 2011.
  11. M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 7, pp. 1911–1930, 2011. View at Publisher · View at Google Scholar · View at PubMed
  12. A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes, “Review: the role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2017–2029, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. R. Bland, D. Markovic, C. E. Hills et al., “Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets,” Journal of Steroid Biochemistry and Molecular Biology, vol. 89-90, pp. 121–125, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. A. Johnson, J. P. Grande, P. C. Roche, and R. Kumar, “Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas,” American Journal of Physiology, vol. 267, no. 3, pp. E356–E360, 1994. View at Google Scholar · View at Scopus
  15. X. Palomer, J. M. González-Clemente, F. Blanco-Vaca, and D. Mauricio, “Role of vitamin D in the pathogenesis of type 2 diabetes mellitus,” Diabetes, Obesity and Metabolism, vol. 10, no. 3, pp. 185–197, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. H. Wolden-Kirk, L. Overbergh, H. T. Christesen, K. Brusgaard, and C. Mathieu, “Vitamin D and diabetes: its importance for beta cell and immune function,” Molecular and Cellular Endocrinology, vol. 347, no. 1-2, pp. 106–120, 2011. View at Publisher · View at Google Scholar · View at PubMed
  17. P. M. Bourlon, B. Billaudel, and A. Faure-Dussert, “Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas,” Journal of Endocrinology, vol. 160, no. 1, pp. 87–95, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. A. W. Norman, B. J. Frankel, A. M. Heldt, and G. M. Grodsky, “Vitamin D deficiency inhibits pancreatic secretion of insulin,” Science, vol. 209, no. 4458, pp. 823–825, 1980. View at Google Scholar · View at Scopus
  19. Y. Tanaka, Y. Seino, M. Ishida et al., “Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin,” Acta Endocrinologica, vol. 105, no. 4, pp. 528–533, 1984. View at Google Scholar · View at Scopus
  20. K. E. Brock, W.-Y. Huang, D. R. Fraser et al., “Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the prostate, lung, colorectal and ovarian cancer screening trial,” British Journal of Nutrition, vol. 106, no. 3, pp. 339–344, 2011. View at Publisher · View at Google Scholar · View at PubMed
  21. G. Grimnes, N. Emaus, R. M. Joakimsen et al., “Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up,” Diabetic Medicine, vol. 27, no. 10, pp. 1107–1115, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. G. Isaia, R. Giorgino, and S. Adami, “High prevalence of hypovitaminosis D in female type 2 diabetic population,” Diabetes Care, vol. 24, no. 8, p. 1496, 2001. View at Google Scholar · View at Scopus
  23. R. Scragg, I. Holdaway, V. Singh, P. Metcalf, J. Baker, and E. Dryson, “Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 27, no. 3, pp. 181–188, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey,” Diabetes Care, vol. 27, no. 12, pp. 2813–2818, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. A. A. Tahrani, A. Ball, L. Shepherd, A. Rahim, A. F. Jones, and A. Bates, “The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK,” International Journal of Clinical Practice, vol. 64, no. 3, pp. 351–355, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. K. M. Behall, D. J. Schofield, J. G. Hallfrisch, J. L. Kelsay, and S. Reiser, “Seasonal variation in plasma glucose and hormone levels in adult men and women,” The American Journal of Clinical Nutrition, vol. 40, no. 6, pp. 1352–1356, 1984. View at Google Scholar
  27. H. Ishii, H. Suzuki, T. Baba, K. Nakamura, and T. Watanabe, “Seasonal variation of glycemic control in type 2 diabetic patients,” Diabetes Care, vol. 24, no. 8, p. 1503, 2001. View at Google Scholar · View at Scopus
  28. J. Mitri, M. D. Muraru, and A. G. Pittas, “Vitamin D and type 2 diabetes: a systematic review,” European Journal of Clinical Nutrition, vol. 65, pp. 1005–1015, 2011. View at Google Scholar
  29. J. Nagpal, J. N. Pande, and A. Bhartia, “A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men,” Diabetic Medicine, vol. 26, no. 1, pp. 19–27, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. A. G. Pittas, S. S. Harris, P. C. Stark, and B. Dawson-Hughes, “The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults,” Diabetes Care, vol. 30, no. 4, pp. 980–986, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. P. R. von Hurst, W. Stonehouse, and J. Coad, “Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial,” British Journal of Nutrition, vol. 103, no. 4, pp. 549–555, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. I. H. de Boer, L. F. Tinker, S. Connelly et al., “Calcium plus vitamin D supplementation and the risk of incident diabetes in the women's health initiative,” Diabetes Care, vol. 31, no. 4, pp. 701–707, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. D. Parekh, V. Sarathi, V. K. Shivane, T. R. Bandgar, P. S. Menon, and N. S. Shah, “Pilot study to evaluate the effect of short-term improvement in vitamin D status on glucose tolerance in patients with type 2 diabetes mellitus,” Endocrine Practice, vol. 16, no. 4, pp. 600–608, 2010. View at Google Scholar
  34. J. Mitri, B. Dawson-Hughes, F. B. Hu, and A. G. Pittas, “Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial,” The American Journal of Clinical Nutrition, vol. 94, no. 2, pp. 486–494, 2011. View at Publisher · View at Google Scholar · View at PubMed
  35. B. Nikooyeh, T. R. Neyestani, M. Farvid et al., “Daily consumption of vitamin D− or vitamin D+ calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial,” The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 764–771, 2011. View at Publisher · View at Google Scholar · View at PubMed
  36. R. Jorde and Y. Figenschau, “Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels,” European Journal of Nutrition, vol. 48, no. 6, pp. 349–354, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. W. Mertz and K. Schwarz, “Relation of glucose tolerance factor to impaired intravenous glucose tolerance of rats on stock diets,” American Journal of Physiology, vol. 196, no. 3, pp. 614–618, 1959. View at Google Scholar · View at Scopus
  38. K. Schwarz and W. Mertz, “Chromium(III) and the glucose tolerance factor,” Archives of Biochemistry and Biophysics, vol. 85, no. 1, pp. 292–295, 1959. View at Google Scholar · View at Scopus
  39. C. M. Davis and J. B. Vincent, “Chromium oligopeptide activates insulin receptor tyrosine kinase activity,” Biochemistry, vol. 36, no. 15, pp. 4382–4385, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. J. B. Vincent, “Elucidating a biological role for chromium at a molecular level,” Accounts of Chemical Research, vol. 33, no. 7, pp. 503–510, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. R. O. Brown, S. Forloines-Lynn, R. E. Cross, and W. D. Heizer, “Chromium deficiency after long-term total parenteral nutrition,” Digestive Diseases and Sciences, vol. 31, no. 6, pp. 661–664, 1986. View at Google Scholar · View at Scopus
  42. H. Freund, S. Atamian, and J. E. Fischer, “Chromium deficiency during total parenteral nutrition,” Journal of the American Medical Association, vol. 241, no. 5, pp. 496–498, 1979. View at Publisher · View at Google Scholar · View at Scopus
  43. K. N. Jeejeebhoy, R. C. Chu, E. B. Marliss, G. R. Greenberg, and A. Bruce-Robertson, “Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long term total parenteral nutrition,” The American Journal of Clinical Nutrition, vol. 30, no. 4, pp. 531–538, 1977. View at Google Scholar · View at Scopus
  44. M. Via, C. Scurlock, J. Raikhelkar, G. Di Luozzo, and J. I. Mechanick, “Chromium infusion reverses extreme insulin resistance in a cardiothoracic ICU patient,” Nutrition in Clinical Practice, vol. 23, no. 3, pp. 325–328, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. S. A. McClave, R. G. Martindale, V. W. Vanek et al., “Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: society of critical care medicine (SCCM) and American society for parenteral and enteral nutrition (A.S.P.E.N.),” Journal of Parenteral and Enteral Nutrition, vol. 33, no. 3, pp. 277–316, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. C. Ekmekcioglu, C. Prohaska, K. Pomazal, I. Steffan, G. Schernthaner, and W. Marktl, “Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls,” Biological Trace Element Research, vol. 79, no. 3, pp. 205–219, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. T. G. Kazi, H. I. Afridi, N. Kazi et al., “Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients,” Biological Trace Element Research, vol. 122, no. 1, pp. 1–18, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  48. D. Ghosh, B. Bhattacharya, B. Mukherjee et al., “Role of chromium supplementation in Indians with type 2 diabetes mellitus,” Journal of Nutritional Biochemistry, vol. 13, no. 11, pp. 690–697, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Rajpathak, E. B. Rimm, T. Li et al., “Lower toenail chromium in men with diabetes and cardiovascular disease compared with healthy men,” Diabetes Care, vol. 27, no. 9, pp. 2211–2216, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. E. M. Balk, A. Tatsioni, A. H. Lichtenstein, J. Lau, and A. G. Pittas, “Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials,” Diabetes Care, vol. 30, no. 8, pp. 2154–2163, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. W. T. Cefalu and F. B. Hu, “Role of chromium in human health and in diabetes,” Diabetes Care, vol. 27, no. 11, pp. 2741–2751, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. C. L. Broadhurst and P. Domenico, “Clinical studies on chromium picolinate supplementation in diabetes mellitus—a review,” Diabetes Technology and Therapeutics, vol. 8, no. 6, pp. 677–687, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. U.S. Food and Drug Administration, Qualified Health Claims: Letter of Enforcement Discretion—Chromium Picolinate and Insulin Resistance (Docket No. 2004Q-0144), 2005.
  54. C. Fernandez-Mejia, “Pharmacological effects of biotin,” The Journal of Nutritional Biochemistry, vol. 16, pp. 424–427, 2005. View at Google Scholar
  55. R. Rodriguez-Melendez and J. Zempleni, “Regulation of gene expression by biotin (review),” Journal of Nutritional Biochemistry, vol. 14, no. 12, pp. 680–690, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. J. C. Coggeshall, J. P. Heggers, M. C. Robson, and H. Baker, “Biotin status and plasma glucose levels in diabetics,” Annals of the New York Academy of Sciences, vol. 447, pp. 389–392, 1985. View at Google Scholar
  57. M. Maebashi, Y. Makino, Y. Furukawa, K. Ohinata, S. Kimura, and S. Takao, “Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin diabetes mellitus,” Journal of Clinical Biochemistry and Nutrition, vol. 14, pp. 211–218, 1993. View at Google Scholar
  58. M. Coupaye, K. Puchaux, C. Bogard et al., “Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study,” Obesity Surgery, vol. 19, no. 1, pp. 56–65, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. M. C. Pflipsen, R. C. Oh, A. Saguil, D. A. Seehusen, and R. Topolski, “The prevalence of vitamin B12 deficiency in patients with type 2 diabetes: a cross-sectional study,” Journal of the American Board of Family Medicine, vol. 22, no. 5, pp. 528–534, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. D. A. de Luis, D. Pacheco, O. Izaola, M. C. Terroba, L. Cuellar, and T. Martin, “Clinical results and nutritional consequences of biliopancreatic diversion: three years of follow-up,” Annals of Nutrition and Metabolism, vol. 53, no. 3-4, pp. 234–239, 2008. View at Publisher · View at Google Scholar · View at PubMed
  61. S. Gehrer, B. Kern, T. Peters, C. Christofiel-Courtin, and R. Peterli, “Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after Laparoscopic Roux-Y-gastric bypass (LRYGB)-a prospective study,” Obesity Surgery, vol. 20, no. 4, pp. 447–453, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. K. Dakshinamurti, V. V. Modi, and S. P. Mistry, “Some aspects of carbohydrates metabolism in biotin-deficient rats,” Proceedings of the Society for Experimental Biology and Medicine, vol. 127, no. 2, pp. 396–400, 1968. View at Google Scholar · View at Scopus
  63. K. Dakshinamurti and C. Cheah-Tan, “Biotin-mediated synthesis of hepatic glucokinase in the rat,” Archives of Biochemistry and Biophysics, vol. 127, no. C, pp. 17–21, 1968. View at Google Scholar · View at Scopus
  64. J. Chauhan and K. Dakshinamurti, “Transcriptional regulation of the glucokinase gene by biotin in starved rats,” Journal of Biological Chemistry, vol. 266, no. 16, pp. 10035–10038, 1991. View at Google Scholar · View at Scopus
  65. H. Sone, M. Ito, K. Sugiyama, M. Ohneda, M. Maebashi, and Y. Furukawa, “Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat,” Journal of Nutritional Biochemistry, vol. 10, no. 4, pp. 237–243, 1999. View at Publisher · View at Google Scholar · View at Scopus
  66. E. Larrieta, M. L. L. de la Vega-Monroy, P. Vital et al., “Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis,” The Journal of Nutritional Biochemistry. In press. View at Publisher · View at Google Scholar · View at PubMed
  67. C. Zendejas-Ruiz I. Fernandez-Mejia, C. Revilla-Monsalve, S. Islas-Andrade, A Báez-Saldaña, and A. Cárdenas, “Biotin treatment increases insulin sensitivity in type 2 diabetics,” Diabetes, vol. 52, supplement, 2003. View at Google Scholar
  68. C. A. Albarracin, B. C. Fuqua, J. L. Evans, and I. D. Goldfine, “Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes,” Diabetes/Metabolism Research and Reviews, vol. 24, no. 1, pp. 41–51, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. G. M. Singer and J. Geohas, “The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial,” Diabetes Technology and Therapeutics, vol. 8, no. 6, pp. 636–643, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. L. Bettendorff and P. Wins, “Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors,” FEBS Journal, vol. 276, no. 11, pp. 2917–2925, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. G. L.J. Page, D. Laight, and M. H. Cummings, “Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease,” International Journal of Clinical Practice, vol. 65, no. 6, pp. 684–690, 2011. View at Publisher · View at Google Scholar · View at PubMed
  72. G. Rindi and U. Laforenza, “Thiamine intestinal transport and related issues: recent aspects (44538),” Experimental Biology and Medicine, vol. 224, no. 4, pp. 246–255, 2000. View at Google Scholar · View at Scopus
  73. US Department of Health and Human Services and US Department of Agriculture, Dietary Guidelines for Americans, US Government Printing Office, Washington, DC, USA, 7th edition, 2010.
  74. D. Lonsdale, “A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives,” Evidence-based Complementary and Alternative Medicine, vol. 3, no. 1, pp. 49–59, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. L. Carrodeguas, O. Kaidar-Person, S. Szomstein, P. Antozzi, and R. Rosenthal, “Preoperative thiamine deficiency in obese population undergoing laparoscopic bariatric surgery,” Surgery for Obesity and Related Diseases, vol. 1, no. 6, pp. 517–522, 2005, discussion 22. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. L. Flancbaum, S. Belsley, V. Drake, T. Colarusso, and E. Tayler, “Preoperative nutritional status of patients undergoing roux-en-Y gastric bypass for morbid obesity,” Journal of Gastrointestinal Surgery, vol. 10, no. 7, pp. 1033–1037, 2006. View at Publisher · View at Google Scholar · View at PubMed
  77. G. Jermendy, “Evaluating thiamine deficiency in patients with diabetes,” Diabetes and Vascular Disease Research, vol. 3, no. 2, pp. 120–121, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  78. N. Saito, M. Kimura, A. Kuchiba, and Y. Itokawa, “Blood thiamine levels in outpatients with diabetes mellitus,” Journal of Nutritional Science and Vitaminology, vol. 33, no. 6, pp. 421–430, 1987. View at Google Scholar · View at Scopus
  79. P. J. Thornalley, R. Babaei-Jadidi, H. Al Ali et al., “High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease,” Diabetologia, vol. 50, no. 10, pp. 2164–2170, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. E. Ascher, P. V. Gade, A. Hingorani et al., “Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells,” Surgery, vol. 130, no. 5, pp. 851–858, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  81. P. I. Lukienko, N. G. Mel'nichenko, I. V. Zverinskii, and S. V. Zabrodskaya, “Antioxidant properties of thiamine,” Bulletin of Experimental Biology and Medicine, vol. 130, no. 9, pp. 874–876, 2000. View at Publisher · View at Google Scholar · View at Scopus
  82. A. Stirban, M. Negrean, B. Stratmann et al., “Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes,” Diabetes Care, vol. 29, no. 9, pp. 2064–2071, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  83. C. Y. Wong, J. Qiuwaxi, H. Chen et al., “Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes,” Molecular Nutrition and Food Research, vol. 52, no. 12, pp. 1421–1427, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  84. R. Z. Fardoun, “The use of vitamin E in type 2 diabetes mellitus,” Clinical and Experimental Hypertension, vol. 29, no. 3, pp. 135–148, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  85. B. Hasanain and A. D. Mooradian, “Antioxidant vitamins and their influence in diabetes mellitus,” Current Diabetes Reports, vol. 2, no. 5, pp. 448–456, 2002. View at Google Scholar · View at Scopus
  86. N. Suksomboon, N. Poolsup, and S. Sinprasert, “Effects of vitamin e supplementation on glycaemic control in type 2 diabetes: systematic review of randomized controlled trials,” Journal of Clinical Pharmacy and Therapeutics, vol. 36, no. 1, pp. 53–63, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  87. M. W. Clarke, J. R. Burnett, and K. D. Croft, “Vitamin E in human health and disease,” Critical Reviews in Clinical Laboratory Sciences, vol. 45, no. 5, pp. 417–450, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. S. Yusuf, G. Dagenais, J. Pogue, J. Bosch, and P. Sleight, “Vitamin E supplementation and cardiovascular events in high-risk patients: the heart outcomes prevention evaluation study investigators,” The New England Journal of Medicine, vol. 342, no. 3, pp. 154–160, 2000. View at Publisher · View at Google Scholar · View at PubMed
  89. F. J. Gómez-Pérez, V. E. Valles-Sánchez, J. C. López-Alvarenga et al., “Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes,” Revista de Investigacion Clinica, vol. 48, no. 6, pp. 421–424, 1996. View at Google Scholar
  90. P. D. Reaven, D. A. Herold, J. Barnett, and S. Edelman, “Effects of vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM,” Diabetes Care, vol. 18, no. 6, pp. 807–816, 1995. View at Google Scholar · View at Scopus
  91. M. Boshtam, M. Rafiei, I. D. Golshadi, M. Ani, Z. Shirani, and M. Rostamshirazi, “Long term effects of oral vitamin E supplement in type II diabetic patients,” International Journal for Vitamin and Nutrition Research, vol. 75, no. 5, pp. 341–346, 2005. View at Publisher · View at Google Scholar · View at Scopus
  92. A. Gazis, D. J. White, S. R. Page, and J. R. Cockcroft, “Effect of oral vitamin E (α-tocopherol) supplementation on vascular endothelial function in type 2 diabetes mellitus,” Diabetic Medicine, vol. 16, no. 4, pp. 304–311, 1999. View at Publisher · View at Google Scholar · View at Scopus
  93. D. Manzella, M. Barbieri, E. Ragno, and G. Paolisso, “Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes,” The American Journal of Clinical Nutrition, vol. 73, no. 6, pp. 1052–1057, 2001. View at Google Scholar · View at Scopus
  94. G. Paolisso, A. D'Amore, D. Giugliano, A. Ceriello, M. Varricchio, and F. D'Onofrio, “Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients,” The American Journal of Clinical Nutrition, vol. 57, no. 5, pp. 650–656, 1993. View at Google Scholar · View at Scopus
  95. K. P. Riess, J. P. Farnen, P. J. Lambert, M. A. Mathiason, and S. N. Kothari, “Ascorbic acid deficiency in bariatric surgical population,” Surgery for Obesity and Related Diseases, vol. 5, no. 1, pp. 81–86, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  96. J. E. Shim, H. Y. Paik, C. S. Shin, K. S. Park, and H. K. Lee, “Vitamin C nutriture in newly diagnosed diabetes,” Journal of Nutritional Science and Vitaminology, vol. 56, no. 4, pp. 217–221, 2010. View at Publisher · View at Google Scholar · View at Scopus
  97. Y. Song, Q. Xu, Y. Park, A. Hollenbeck, A. Schatzkin, and H. Chen, “Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults,” Diabetes Care, vol. 34, no. 1, pp. 108–114, 2011. View at Publisher · View at Google Scholar · View at PubMed
  98. J. C. Will, E. S. Ford, and B. A. Bowman, “Serum vitamin C concentrations and diabetes: findings from the third National Health and Nutrition Examination Survey, 1988–1994,” The American Journal of Clinical Nutrition, vol. 70, no. 1, pp. 49–52, 1999. View at Google Scholar · View at Scopus
  99. G. Paolisso, V. Balbi, C. Volpe et al., “Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics,” Journal of the American College of Nutrition, vol. 14, no. 4, pp. 387–392, 1995. View at Google Scholar · View at Scopus
  100. H. Chen, R. J. Karne, G. Hall et al., “High-dose oral vitamin C partially replenishes vitamin C levels in patients with type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance,” American Journal of Physiology, vol. 290, no. 1, pp. H137–H145, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  101. Y. Handelsman, J. I. Mechanick, L. Blonde et al., “American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan: executive summary,” Endocrine Practice, vol. 17, no. 2, pp. 287–302, 2011. View at Google Scholar