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ISRN Endocrinology
Volume 2012 (2012), Article ID 103714, 7 pages
Clinical Study

Quick and Simple Evaluation of Sudomotor Function for Screening of Diabetic Neuropathy

1Diabetes Unit, King Edward Memorial Hospital Research Centre, Rasta Peth, Maharashtra 411011, Pune, India
2Aesculape, Singapore

Received 28 March 2012; Accepted 28 April 2012

Academic Editors: E. Hajduch and J. Nedvídková

Copyright © 2012 Chittaranjan S. Yajnik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study was to compare SUDOSCAN, a new device to evaluate sweat function (reflecting peripheral small C-fiber status), with conventional measures of peripheral and cardiac neuropathy in patients with type 2 diabetes. Methods. 265 diabetic patients were tested for symptoms and clinical signs of neuropathy using Michigan Neuropathy Screening Instrument (MNSI), vibration perception threshold (VPT) using biothesiometer, and cardiac autonomic neuropathy (CAN) using Ewing’s protocol. Sudomotor function was investigated with SUDOSCAN through measurement of electrochemical skin conductance (ESC) of hands and feet. Lower ESC is suggestive of sudomotor dysfunction. Results. Lower ESC at feet was significantly associated both with increasing symptoms (MNSI A) and increasing score on physical abnormalities (MNSI B). Lower ESC at feet was also significantly associated with increasing VPT by biothesiometry ( 𝑃 < 0 . 0 1 ), and with higher number of abnormal CAN results ( 𝑃 < 0 . 0 5 ). ESC was associated with postural fall in blood pressure (sympathetic abnormality) ( 𝑃 < 0 . 0 5 ), but not with heart rate variability (HRV) tests (parasympathetic abnormalities). Conclusions. Sudomotor dysfunction testing may be a simple test to alert physicians to peripheral nerve and cardiac sympathetic dysfunction. Ease of performance could make it useful in a busy diabetic clinic. Further studies with hard clinical outcomes are indicated.