Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 104540, 7 pages
http://dx.doi.org/10.5402/2012/104540
Research Article

Activity of Cuban Plants Extracts against Leishmania amazonensis

1Department of Parasitology, Institute of Tropical Medicine “Pedro Kourí,” Apdo Postal No. 601, Havana 10400, Cuba
2Department of Chemistry, Institute of Pharmacy and Food, University of Havana, Havana 10400, Cuba
3Department of Systematic, Institute of Ecology and Systematic, Havana 10400, Cuba

Received 14 November 2011; Accepted 4 January 2012

Academic Editors: S. Tokuyama and T. B. Vree

Copyright © 2012 Marley García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a major health problem worldwide that affects millions of people especially in the developing nations. There is no immunoprophylaxis (vaccination) available for Leishmania infections, and conventional treatments are unsatisfactory; therefore, antileishmanial drugs are urgently needed. In this work, 48 alcoholic extracts from 46 Cuban plants were evaluated by an in vitro bioassay against Leishmania amazonensis. Furthermore, their toxicity was assayed against murine macrophage. The three most potent extracts against the amastigote stage of Leishmania amazonensis were from Hura crepitans, Bambusa vulgaris, and Simarouba glauca.