Table of Contents
ISRN Organic Chemistry
Volume 2012, Article ID 104975, 4 pages
Research Article

Microwave-Assisted Hydrogenation of Codeine in Aqueous Media

1Department of Chemical Engineering, Faculty of Engineering, Uşak University, 64200 Uşak, Turkey
2Department of Chemistry, Faculty of Arts and Sciences, Uşak University, 64200 Uşak, Turkey

Received 8 August 2012; Accepted 15 September 2012

Academic Editors: F. V. Gonzalez and F. L. Van Delft

Copyright © 2012 F. Taktak and I. Bulduk. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient one-pot microwave-assisted hydrogenation of codeine was achieved in aqueous solution. This technique is simple, fast, environmentally friendly, and highly efficient. Structure of produced dihydrocodeine was approved by using FT-IR, 1H NMR, 13C NMR, EIMS, and elemental analysis technique. Its purity analysis was performed by using HPLC and assay analysis was performed by using potentiometric titration methods.