Table of Contents
ISRN Analytical Chemistry
Volume 2012, Article ID 132543, 5 pages
http://dx.doi.org/10.5402/2012/132543
Research Article

Nuclear Magnetic Resonance Analysis of Glucose Levels in Weanling Piglets Plasma as a Function of Deoxynivalenol Exposure

1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
2Molecular Epidemiology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
3INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France
4MIAEH, School of Public Health, University of Maryland, College Park, MD, USA

Received 30 August 2012; Accepted 16 October 2012

Academic Editors: P. Campíns-Falcó, T. Macko, and A. Tsantili-Kakoulidou

Copyright © 2012 Richard P. Hopton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Deoxynivalenol (DON) is a mycotoxin contaminant of cereal crops, and whilst animal toxicity has demonstrated its role at low doses in animals, and in human toxicity in general remains unclear. Here we investigated potential biological markers in sera using samples obtained from a previous DON-controlled feeding study on weanling piglets. Piglets ( per group) received diets containing 0 (control), 240, 560-or 840 μg DON/kg feed for 28 days. Plasma samples collected at the end of the DON exposure trial were reassessed, using nuclear magnetic resonance (NMR). A modest trend was observed between plasma glucose concentration and DON ingestion ( ). Plasma DON ( ) and plasma protein-associated DON ( ) were moderately correlated with DON ingestion in a more limited survey of a subset of samples used for glucose analysis ( ). This is a preliminary study but suggests that a more detailed survey of the temporal nature of these biological measures is warranted.