Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 162802, 10 pages
http://dx.doi.org/10.5402/2012/162802
Research Article

C-Peptide Reduces Mitochondrial Superoxide Generation by Restoring Complex I Activity in High Glucose-Exposed Renal Microvascular Endothelial Cells

1Department of Physiology and Pharmacology, West Virginia University School of Medicine, P.O. Box 9105, Morgantown, WV 26506, USA
2Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
3Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA

Received 14 March 2012; Accepted 10 April 2012

Academic Editors: O. Giampietro, J. Pachucki, and H. Tamemoto

Copyright © 2012 Himani Vejandla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Patrizia Luppi, Åsa Kallas, and John Wahren, “Can C-peptide mediated anti-inflammatory effects retard the development of microvascular complications of type 1 diabetes?,” Diabetes/Metabolism Research and Reviews, vol. 29, no. 5, pp. 357–362, 2013. View at Publisher · View at Google Scholar
  • Mahendra Prasad Bhatt, Young-Cheol Lim, Young-Myeong Kim, and Kwon-Soo Ha, “C-Peptide Activates AMPK alpha and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes,” Diabetes, vol. 62, no. 11, pp. 3851–3862, 2013. View at Publisher · View at Google Scholar
  • M. P. Bhatt, Y.-C. Lim, and K.-S. Ha, “C-peptide replacement therapy as an emerging strategy for preventing diabetic vasculopathy,” Cardiovascular Research, 2014. View at Publisher · View at Google Scholar
  • Gina L. C. Yosten, Christine Maric-Bilkan, Patrizia Luppi, and John Wahren, “Physiological effects and therapeutic potential of proinsulin C-peptide,” American Journal Of Physiology-Endocrinology And Metabolism, vol. 307, no. 11, pp. E955–E968, 2014. View at Publisher · View at Google Scholar
  • Patrizia Luppi, and Peter Drain, “Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress,” Diabetes/Metabolism Research and Reviews, vol. 30, no. 7, pp. 599–609, 2014. View at Publisher · View at Google Scholar
  • P. Luppi, and P. Drain, “C-peptide antioxidant adaptive pathways in β cells and diabetes,” Journal of Internal Medicine, 2016. View at Publisher · View at Google Scholar
  • Michelle Teodoro Alves, Mylena Maira Oliveira Ortiz, Guilherme Victor Oliveira Pimenta dos Reis, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho, Ana Paula Fernandes, and Karina Braga Gomes, “The dual effect of C-peptide on cellular activation and atherosclerosis: Protective or not?,” Diabetes/Metabolism Research and Reviews, pp. e3071, 2018. View at Publisher · View at Google Scholar