C-Peptide Reduces Mitochondrial Superoxide Generation by Restoring Complex I Activity in High Glucose-Exposed Renal Microvascular Endothelial Cells
Figure 2
(a) At 24 hours, high glucose resulted in significant mitochondrial membrane hyperpolarization. Subsequently, endothelial mitochondria were depolarized (after 48 hours). Treatment with C-peptide resulted in restoration of m at both 24 and 48 hours of exposure to a high glucose stress. *, significantly greater than low-glucose and high-glucose + C-peptide (); #, significantly less than low-glucose and high-glucose + C-peptide (). Data represent means ± SEM and experiments. (b) Representative fluorescence micrographs of renal MECs treated with JC-1.
(a)
(b)
We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.