International Scholarly Research Notices

Research Article

How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder: Methylphenidate Improves Autonomic Dysfunction in Children with ADHD

Table 1

Heart rate variability in healthy children ( 𝑛 = 1 9 ), children with ADHD untreated ( 𝑛 = 1 2 ) and treated with methylphenidate (MPH) ( 𝑛 = 1 9 ).
Mean ± SDP 1 versus 2P 2 versus 3P 1 versus 3
Age (years)
 Healthy 10.8 ± 3.5
 ADHD10.8 ± 2.0 𝑃 = n s 𝑃 = n s 𝑃 = n s
 ADHD + MPH10.6 ± 2.8
Heart rate (/min.)
 Healthy85 ± 10
 ADHD94 ± 7 𝑃 = 0 . 0 0 3 𝑃 = 0 . 0 4 𝑃 = n s
 ADHD + MPH90 ± 6
SDNN (ms)
 Healthy146 ± 30
 ADHD136 ± 41 𝑃 = n s 𝑃 = n s 𝑃 = n s
 ADHD + MPH151 ± 25
rMSSD (ms)
 Healthy44 ± 10
 ADHD26 ± 4 𝑃 < 0 . 0 0 0 1 𝑃 = 0 . 0 0 0 1 𝑃 = 0 . 0 0 8
 ADHD + MPH36 ± 8
pNN50 (%)
 Healthy21.5 ± 9.0
 ADHD6.5 ± 2.7 𝑃 = 0 . 0 0 0 1 𝑃 = 0 . 0 0 0 2 𝑃 = 0 . 0 0 8
 ADHD + MPH14.2 ± 6.9
Values are given in mean ± SD. Probability of difference using student 𝑡 -test; significant values are in bold; SDNN: standard deviation of all NN intervals; rMSSD: square root of the mean of the sum of the squares of differences between adjacent NN intervals; pNN50: number of pairs of adjacent NN intervals differing by more than 50 ms divided by the total number of all NN intervals.