Table of Contents
ISRN Orthopedics
Volume 2012, Article ID 182097, 9 pages
http://dx.doi.org/10.5402/2012/182097
Research Article

An Assessment of the Chondroprotective Effects of Intra-Articular Application of Statin and Tetracycline on Early-Stage Experimental Osteoarthritis

1Department of Orthopaedics and Traumatology, Nizip State Hospital, Gaziantep, Turkey
2Ortopedi ve Travmatoloji Bölümü, Tıp Fakültesi, Uludağ Üniversitesi, 16059, Görükle Kampüsü, Bursa, Turkey

Received 20 February 2012; Accepted 28 March 2012

Academic Editors: S. Aldrian, R. Assietti, J. D. Lurie, G. Matthes, S. Sharma, and B. K. Weiner

Copyright © 2012 Mustafa Dinc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To compare the effects of intra-articular application of statin and tetracyclines on cartilage and synovial tissue on experimental osteoarthritis. Methods. Osteoarthritis was created in 30 rabbits of 3 groups. The control group received saline intra-articularly, statin group, atorvastatin and the tetracycline group, doxycycline once a week for 3 weeks. Chondral and synovial tissues were evaluated macroscopically and histopathologically. Results. Macroscopic evaluation determined mean values of control group 3.0, statin group 0.56, and tetracycline group 2.5. Histopathological evaluations determined mean values; femoral medial condyle cartilage tissue, control group, 1 4 . 6 0 ± 1 . 0 0 , statin group 2 . 2 0 ± 1 . 3 0 , tetracycline group 1 2 . 7 ± 5 . 3 9 : tibia medial plateau, control group, 1 4 . 3 3 ± 8 . 6 8 , statin group 2 . 8 9 ± 1 . 9 6 , tetracycline group, 1 5 . 9 0 ± 7 . 0 3 : synovial tissue, control group 1 2 . 2 2 ± 3 . 6 3 , statin group 4 . 3 3 ± 2 . 6 9 , tetracycline group 1 0 . 7 0 ± 2 . 6 2 . Average values of synovial tissue cell layer thickness were control group 1 4 . 4 6 ± 2 . 3 5 μm, statin group 1 0 . 5 6 ± 1 . 0 1 μm, tetracycline group 1 2 . 8 0 ± 0 . 7 9 μm. All measurements showed statistically significant differences between statin and control groups ( 𝑃 < 0 . 0 5 ) but not between tetracycline and control groups ( 𝑃 > 0 . 0 5 ). Conclusions. Tetracycline has little effect due to chemical modification requirement, and the effect is dose dependent. Statins have chondroprotective effects, so may become a novel therapeutic agent in osteoarthritis management after chemical processing.