Table of Contents
ISRN Allergy
Volume 2012, Article ID 183983, 9 pages
Research Article

Clinical and Immunological Changes of Immunotherapy in Patients with Atopic Dermatitis: Randomized Controlled Trial

1Group of Clinical and Experimental Allergy, University of Antioquia, Medellin, Colombia
2Foundation for the Development of Medical and Biological Sciences (FUNDEMEB), Cartagena, Colombia
3Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
4IPS Universitaria Sede Ambulatoria, Universidad de Antioquia Carrera 51A No. 62-42, Medellin, Colombia

Received 26 November 2011; Accepted 10 January 2012

Academic Editors: S. Burastero, A. Lorentz, B. M. Stadler, and B. Xu

Copyright © 2012 Jorge Mario Sánchez Caraballo and Ricardo Cardona Villa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Immunotherapy has proven to be an useful tool in the management of allergic respiratory diseases; however, little has been studied in atopic dermatitis. Objective. To evaluate the clinical and immunological impact of immunotherapy with mites allergen extracts in atopic dermatitis. Methods. Patients with atopic dermatitis were assigned with computer-generated randomization to either of the following groups: (a) controls received only topical treatment with steroids and/or tacrolimus and (b) actively treated patients received topical treatment plus immunotherapy. Levels of serum total IgE, mites-specific IgE and IgG4 were assessed at study start and after one year of immunotherapy. Results. 31 patients in the active group and 29 in the control group completed the study. Symptoms and medication scores were significantly reduced in the active group after six months. Three patients in the control group showed new sensitizations to mites, while 3 patients in the active group showed neosensitization to shrimp with negative oral food challenge. We observed significant increase of mites-specific IgG4 levels in active group. Conclusion. Specific allergen immunotherapy induced a tolerogenic IgG4 response to mite allergens associated with favorable clinical effects in atopic dermatitis patients.